Results 181 to 190 of about 396,778 (337)

Domain arrangements of ADAMTS, ADAMs and MMPs

open access: green, 2011
Hideaki Nagase, Masahide Kashiwagi
openalex   +1 more source

Nazal polipli kronik rinosinüzitlerde MMP-1, MMP-2, MMP-8 düzeyinin değerlendirilmesi

open access: yes, 2021
The pathogenesis of nasal polyposis could not be elucidated fully. However,a lot of factors available etiology to be were identified.Metalloproteinases are important proteins in tissue remodeling; they act degradationupon almost all of the extracellular matrix (ECM) elements. Thus they take an activerole on tissue remodeling.
openaire   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

open access: yesAdvanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong   +5 more
wiley   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li   +15 more
wiley   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

open access: yesAdvanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang   +12 more
wiley   +1 more source

Unravelling the Contribution of Matrix Metalloproteinase-3 Genotype-Phenotype to Pterygium Risk. [PDF]

open access: yesCancer Genomics Proteomics
Chen HC   +10 more
europepmc   +1 more source

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