Results 191 to 200 of about 390,769 (349)

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Monoclonal antibodies inhibiting MMP-9 activity alleviate peripheral neuropathy in diabetic mice. [PDF]

Sci Transl Med
Lee KB, He W, Matsuoka Y, Bang S, Krishnan S, Xu J, Zhang Q, Ma L, Hu W, Ao X, Parisien M, Diatchenko L, Liu X, Ji RR, Ge X.   +14 more
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Rituximab in Mucous Membrane Pemphigoid: Current Evidence and Clinical Perspectives. [PDF]

Healthcare (Basel)
Popa LG, Giurcaneanu C, Coviltir V, Popescu C, Ali S, Cozma M, Orzan OA.   +6 more
europepmc   +1 more source

Influence of Self-polymerizing Dental Resins on MMP-2 AND MMP-9 Genes

, 2013
Objective: The present in vitro study aimed to evaluating the potential cytotoxicity of self-polymerizing dental resins on human gingival fibroblasts (HGFs) isolated from healthy patients.
SIMEONE M, RICCITIELLO, FRANCESCO, PROCINO A, ZARONE F, RIVIECCIO V, RENGO S., BORRELLI B, SORRENTINO, Roberto   +7 more
core  

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Salivary Melatonin and MMP-9 Levels in Stage III Periodontitis: A Pilot Study Using Standardized Pre-Sleep Saliva Collection. [PDF]

Medicina (Kaunas)
Ivanov I, Naseva E, Mlachkova A, Dosseva-Panova V, Pashova-Tasseva Z, Maynalovska H, Kirilov B, Petrova V, Ishkitiev N, Apostolova S.   +9 more
europepmc   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Role of Rab4A in the enhancement of cancer cell invasion induced by plasma samples collected during radiotherapy in patients with triple-negative breast cancer. [PDF]

PLoS One
Paquette B, Therriault H, Gauthier I, Provencher S, Bourque JM, Naasri S, Oweida A, Geha S, Labrecque P, Parent JL.   +9 more
europepmc   +1 more source

Electronics‐Free Visual Monitoring of Dry Eye Disease‐Related Tear Biomarkers Using Smart Scleral Lenses

Advanced Science, EarlyView.
An electronics‐free smart scleral lens passively monitors dry eye disease‐related tear biomarkers through colorimetric sensing of chloride, pH, and ocular surface temperature. Smartphone‐assisted image analysis enables quantitative interpretation, providing a simple, non‐invasive strategy for ocular health monitoring without integrated electronics ...
Ziheng Wang, Sang Mok Park, Dawn Meyer, Seul Ah Lee, Yumin Dai, Tianhao Yu, Taewoong Park, Feiyang Li, Jason Gerard Jedlicka, Tristan Michael Long, Oluwabunmi T. Oladele, Gillian C. Shaw, Shin Ae Park, Pete S. Kollbaum, Young L. Kim, Chi Hwan Lee   +15 more
wiley   +1 more source