Results 221 to 230 of about 121,710 (296)

Data‐driven thresholds for standardized classification of severe Alzheimer's disease neuropathology using digital neuropathology

Brain Pathology, Volume 36, Issue 6, November 2026.
We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson   +10 more
wiley   +1 more source

Navigating the Challenges of Shared Decision‐Making in Amyloid Immunotherapy for Alzheimer's Disease

European Journal of Neurology, Volume 33, Issue 11, November 2026.
ABSTRACT Background Anti‐amyloid therapies (AATs), such as lecanemab and donanemab, represent a major therapeutic development for early Alzheimer's disease (AD). However, safety risks and uncertainties regarding long‐term effects make treatment decisions complex.
Grâce François, Robin Michalon, Thomas Tannou, Philippe Damier, Sonia Desmoulin, Thibaud Lebouvier   +5 more
wiley   +1 more source

Vitamin D Supplementation and Mortality in the Elderly: A Review of a Meta‐Analysis of Randomized Controlled Trials Using the REB Method

Fundamental &Clinical Pharmacology, Volume 40, Issue 6, November 2026.
ABSTRACT Background The results of randomized controlled trials (RCTs) regarding the effect of vitamin D supplementation on mortality reduction are conflicting. Objective The aim of this study was to assess the level of evidence through a sensitivity analysis of the meta‐analysis by Shah et al.
Natalia Kostakis, Jean‐Christophe Lega, Remy Boussageon   +2 more
wiley   +1 more source

Clock Drawing Test Performance in Rural Vietnam: Reliability and Concurrent Validity Relative to the Mini‐Mental State Examination in a Community‐Based Sample

Geriatrics &Gerontology International, Volume 26, Issue 11, November 2026.
In 1073 older adults in rural Khanh Hoa, Vietnam, the Clock Drawing Test showed modest discrimination for low cognitive performance defined as MMSE ≤ 23 (AUC 0.68). Although the negative predictive value was high (94%), its utility for cognitive screening remains uncertain.
Aki Yazawa, Thuy Thi Phuong Pham, Chau Que Nguyen, Aoi Ito, Danh Cong Phan, Masahiko Hachiya, Thanh Tien Hoang, Hung Thai Do, Tetsuya Mizoue, Yosuke Inoue   +9 more
wiley   +1 more source

Serial Mediation Pathways Linking Physical Performance to EQ-VAS-Assessed Self-Rated Health in Older Inpatients. [PDF]

Healthcare (Basel)
Băjenaru OL, Băjenaru L, Balog A, Chelu GC, Constantinescu A, Andronic O, Nuță CR.   +6 more
europepmc   +1 more source

Exploring the interplay between frailty, Alzheimer's disease biomarkers, and cognitive functioning in patients with mild cognitive impairment: A cross-sectional study. [PDF]

J Alzheimers Dis
Pintus M, Valletta M, Sacchi L, Carandini T, Ghezzi L, Pietroboni A, Fenoglio C, Serpente M, Arcaro M, Bruno G, Galimberti D, Canevelli M, Arighi A.   +12 more
europepmc   +1 more source

An Ecological and Processual Understanding of Family Resilience in Dementia: A Qualitative Meta‐Synthesis

Journal of Advanced Nursing, Volume 82, Issue 11, Page 9730-9750, November 2026.
ABSTRACT Aim To explore how family resilience emerges and unfolds in dementia. Design Qualitative meta‐synthesis using thematic synthesis. Data Sources PubMed, CINAHL, Web of Science, PsycINFO were searched from inception through August 26, 2025. Methods Studies examining family‐level resilience, adaptation or coping in home‐based dementia care using ...
Yoosun Yang, Jun‐Ah Song
wiley   +1 more source

Factor structure of the neuropsychological battery in the Mexican Cognitive Aging Ancillary Study (Mex-Cog). [PDF]

Neuropsychology
Kamalyan L, Kunicki ZJ, Jeon S, Yang G, Mejia-Arango S, Obregon AM, Wong R, Saenz J, Briceño EM, Arce Rentería M.   +9 more
europepmc   +1 more source

Levodopa and Subthalamic Nucleus Deep Brain Stimulation Modulate Excitation/Inhibition Balance and the Neural Encoding of Isochronous Sequences in Persons With Parkinson's Disease

Annals of the New York Academy of Sciences, Volume 1565, Issue 1, November 2026.
In this study, we show that levodopa and deep brain stimulation (DBS) interventions differently modulate excitation/inhibition balance at the brain level and how individuals with Parkinson's disease process temporally regular auditory sequences, as typically provided in rhythmic auditory cueing protocols.
Antonio Criscuolo, Michael Schwartze, Johannes Schwarz, Karl Strecker, Swen Hesse, Sonja A. Kotz   +5 more
wiley   +1 more source