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Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue

Viruses, 2022
Since its discovery as a milk factor, mouse mammary tumor virus (MMTV) has been shown to cause mammary carcinoma and lymphoma in mice. MMTV infection depends upon a viral superantigen (sag)-induced immune response and exploits the immune system to ...
Francesca Parisi, Giulia Freer, Chiara Maria Mazzanti, Mauro Pistello, Alessandro Poli   +4 more
doaj   +4 more sources

Mouse Mammary Tumour Virus (MMTV) in Human Breast Cancer—The Value of Bradford Hill Criteria

Viruses, 2022
For many decades, the betaretrovirus, mouse mammary tumour virus (MMTV), has been a causal suspect for human breast cancer. In recent years, substantial new evidence has been developed.
James S. Lawson, Wendy K. Glenn
doaj   +2 more sources

Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice. [PDF]

PLoS ONE, 2015
p53 is an important tumor suppressor gene which is mutated in ~50% of all human cancers. Some of these mutants appear to have acquired novel functions beyond merely losing wild-type functions.
Dadi Jiang, Catherine I Dumur, H Davis Massey, Viswanathan Ramakrishnan, Mark A Subler, Jolene J Windle   +5 more
doaj   +5 more sources

Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression. [PDF]

PLoS ONE, 2008
Matrix metalloproteinase (MMP) 13 (collagenase 3) is an extracellular matrix remodeling enzyme that is induced in myofibroblasts during the earliest invasive stages of human breast carcinoma, suggesting that it is involved in tumor progression.
Boye S Nielsen, Mikala Egeblad, Fritz Rank, Hanne A Askautrud, Caroline J Pennington, Tanja X Pedersen, Ib J Christensen, Dylan R Edwards, Zena Werb, Leif R Lund   +9 more
doaj   +19 more sources

Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice [PDF]

Breast Cancer Research, 2015
Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity which has onco-suppressive actions in numerous tumor ...
A Dufour, A Gutierrez-Fernandez, A Gutiérrez-Fernández, A Krüger, AM Tester, Ana Gutiérrez-Fernández, B Fingleton, B Fingleton, C López-Otín, C Soria-Valles, CM Overall, CT Guy, D Agarwal, Dylan R Edwards, E Dejonckheere, EI Deryugina, EM Bekes, EY Lin, EY Lin, G Christoffersson, G Dew, H Nozawa, J Decock, J Decock, J Decock, J Decock, J Schindelin, J Wyckoff, JE Maglione, JP Väyrynen, JP Witty, JT Korpi, JT Korpi, Julie Decock, K Almholt, L Sevenich, LH Palavalli, LJ McCawley, M Balbin, M Egeblad, M Hernández, M Lin, M Zhu, MM Gueders, N Fortelny, N Xu, P Li, P Lint Van, S Tazzyman, S Thirkettle, Sally Thirkettle, Stephen D Robinson, T Pellinen, T-Y Wu, V Knäuper, V Montel, W Wang, Wouter Hendrickx, Y Lang, Y-H Lin, Z Yang, Z-G Zhao, ZG Fridlender   +62 more
core   +4 more sources

Is MMTV associated with human breast cancer? Maybe, but probably not

Virology Journal, 2017
Background Conflicting results regarding the association of MMTV with human breast cancer have been reported. Published sequence data have indicated unique MMTV strains in some human samples.
Raisa Perzova, Lynn Abbott, Patricia Benz, Steve Landas, Seema Khan, Jordan Glaser, Coleen K. Cunningham, Bernard Poiesz   +7 more
doaj   +2 more sources

Prevalence of Mouse Mammary Tumor Virus (MMTV)-like sequences in human breast cancer tissues and adjacent normal breast tissues in Saudi Arabia

BMC Cancer, 2018
Background Breast cancer is considered the most common cancer in women worldwide and is the leading cause of cancer mortality. Sequences similar to Mouse Mammary Tumor Virus (MMTV) were detected in human breast cancer in several studies from different ...
Reem Al Dossary, Khaled R. Alkharsah, Haitham Kussaibi   +2 more
doaj   +2 more sources

Protease-mediated maturation of M-PMV reverse transcriptase into a functional heterodimer. [PDF]

Protein Sci
Abstract Reverse transcriptase (RT) of retroviruses orchestrates viral replication, yet its structural diversity remains poorly understood. Well‐studied RTs, such as those from HIV‐1, murine leukemia virus, and avian myeloblastosis virus, were characterized decades ago, but less prominent retroviruses have escaped detailed analysis.
Kapisheva M, Junková P, Vaněk O, Jalovcová Z, Křížová I, Dostálková A, Rumlová M.   +6 more
europepmc   +2 more sources

Decitabine suppresses tumor growth by activating mouse mammary tumor virus and interferon-β pathways [PDF]

Biomolecules & Biomedicine
Decitabine (DAC), a DNA methyltransferase inhibitor (DNMTi), is clinically effective in hematological malignancies such as myelodysplastic syndrome and acute myeloid leukemia, but its precise antineoplastic mechanisms remain incompletely understood ...
Ryan Johnson, Andrew Brola, Cade Wycoff, William Wycoff, Seth Neumeyer, Richard Tuttle, Sarah Light, Jiayi Li, Stephen Christensen, Yingguang Liu   +9 more
doaj   +2 more sources

X-ray structure of the MMTV-A nucleosome core [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance The DNA in eukaryotic organisms is packaged in nucleosomes, the fundamental repeating unit of chromatin. The ability of essential transcription regulatory factors to bind genomic recognition sites is contingent on the sequence-dependent conformation of DNA bound in nucleosomes.
T. Frouws, Sylwia Duda, T. Richmond
semanticscholar   +3 more sources