Results 101 to 110 of about 38,824 (244)

Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages [PDF]

, 2007
Genetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)‐induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy.
Barleon, Cho, de Felipe, Dong, Donnelly, Dvorak, Elaine Y. Lin, Eubank, Ferrara, Ferrara, Folkman, Gabriel Bricard, Giraudo, Gouon-Evans, Grunewald, Gunther, Guy, Hanahan, Jain, Jeffrey W. Pollard, Jiu-feng Li, Keyt, Kumaraswamy, Leek, Leek, Leek, Leung, Lewis, Lin, Lin, Lin, Lin, Lobov, Mok, Naumov, Pollard, Rani Sellers, Ross, Sasmono, Schoeffner, Scholl, Shima, Steven A. Porcelli, Sunderkotter, Varney, Weigang Wang, Yan Deng, Yoshida   +47 more
core   +1 more source

Late developing mammary tumors and hyperplasia induced by a low-oncogenic variant of mouse mammary tumor virus (MMTV) express genes identical to those induced by canonical MMTV

Molecular Cancer, 2013
The canonical milk-transmitted mouse mammary tumor virus (MMTV) of C3H mice (C3H-MMTV) rapidly induces tumors in 90% of infected animals by 8 months of age.
Robert D. Bruno, Sonia M. Rosenfield, Gilbert H Smith   +2 more
semanticscholar   +1 more source

Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology

Advanced Healthcare Materials, Volume 15, Issue 1, 9 January 2026.
In vitro breast cancer models that closely mimic the complex biological and cellular interactions within the tumor microenvironment hold strong promise for enhancing our understanding of tumor progression, immune system behavior, and resistance to therapies, which are essential for developing personalized cancer treatments. Abstract Engineered in vitro
Wonwoo Jeong, Sang Jin Lee
wiley   +1 more source

Mouse mammary tumor virus-like gene sequences are present in lung patient specimens

Virology Journal, 2011
Background Previous studies have reported on the presence of Murine Mammary Tumor Virus (MMTV)-like gene sequences in human cancer tissue specimens.
Rodríguez-Padilla Cristina, Tamez-Guerra Reyes, Garza-Sáenz Jorge A, Morán-Santibañez Karla, Zamora-Avila Diana E, Saavedra-Alonso Santiago, Barrera-Rodríguez Raúl, Badillo-Almaráz Isaías, Zapata-Benavides Pablo, Trejo-Avila Laura M   +9 more
doaj   +1 more source

Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Banerji, Becker, Becker, Buetti, Cartwright, Chandler, Chen, Church, DeFranco, Gilbert, Gluecksohn-Waelsch, Gorman, Granner, Greengard, Hargrove, Hashimoto, Hochschild, Hynes, Karin, Karin, Killary, Maniatis, Maxam, Melton, Miksicek, Payvar, Pelham, Ptashne, Renkawitz, Ringold, Ruiz-Bravo, Scheidereit, Scherer, Schmid, Searle, Serfling, Sergeant, Singh, Slater, Yamamoto, Zaret, Zinn   +41 more
core   +1 more source

MMTV-Espl1 Transgenic Mice Develop Aneuploid, Estrogen Receptor Alpha (ERα)-Positive Mammary Adenocarcinomas

Oncogene, 2013
Separase, a protease encoded by the ESPL1 gene, cleaves the chromosomal cohesin during mitosis. Separase protein and transcripts are overexpressed in a wide range of human cancers.
M. Mukherjee, Gouqing Ge, Nenggang Zhang, D. Edwards, Pavel Sumazin, S. K. Sharan, P. Rao, D. Medina, D. Pati   +8 more
semanticscholar   +1 more source

Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy

Advanced Materials, Volume 38, Issue 3, 13 January 2026.
Weakly assembled peptide amphiphile nanostructures disassemble in circulation and reassemble with blood biomolecules, mainly lipoproteins. Binding to blood biomolecules prolongs blood circulation and improves accumulation in solid tumors. In the tumor microenvironment, peptide amphiphiles assemble with cholesterol‐rich domains of cell membranes ...
Li Xiang, Morgan R. Stewart, Kailin Mooney, Mingchong Dai, Samuel Drennan, Samantha Holland, Arnaud Quentel, Sinan Sabuncu, Benjamin R. Kingston, Isabel J. Dengos, Karla Bonic, Florian Goncalves, Xin Yi, Michael I. Henderson, Srivathsan Ranganathan, Bruce P. Branchaud, Leslie L. Muldoon, Ramon F. Barajas Jr, Jared M. Fischer, Adem Yildirim   +19 more
wiley   +1 more source

Transgenic mice with mammary gland targeted expression of human cortactin do not develop (pre-malignant) breast tumors: studies in MMTV-cortactin and MMTV-cortactin/-cyclin D1 bitransgenic mice

BMC Cancer, 2006
Background In human breast cancers, amplification of chromosome 11q13 correlates with lymph node metastasis and increased mortality. To date, two genes located within this amplicon, CCND1 and EMS1, were considered to act as oncogenes, because ...
van Krieken Johan HJM, van der Ploeg Jan CM, Schuuring-Scholtes Ellen, van Bragt Maaike PA, van Rossum Agnes GSH, Kluin Philip M, Schuuring Ed   +6 more
doaj   +1 more source

Introduction to Deadly Delusions #5 [PDF]

, 2018
Barry Mauer began the comic series Deadly Delusions in 2013 in response to the increasingly extreme and dangerous right-wing propaganda he had observed over the past several decades.
Mauer, Barry
core  

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source