Results 121 to 130 of about 38,824 (244)

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
wiley   +1 more source

APC selectively mediates response to chemotherapeutic agents in breast cancer [PDF]

, 2015
BACKGROUND: The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in up to 70 % of sporadic breast cancers depending on subtype; however, the effects of APC mutation on tumorigenic properties remain unexplored. Using the Apc(
Claire O. Bedalov, Jenifer R. Prosperi, Katia Fernandez Soto, Monica K. VanKlompenberg   +3 more
core   +3 more sources

Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice

Oncogene, 2013
Little is known about chromatin mechanisms that regulate tumor-initiating cells that are proposed to be responsible for tumor recurrence and relapse.
Kazuhide Watanabe, Magid Fallahi, X. Dai
semanticscholar   +1 more source

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source

Relation between the Presence of Mouse Mammary Tumor Virus-Like Sequences in Breast Tissues and Human Breast Cancer in Iranian Patients

مجله دانشکده پزشکی اصفهان, 2013
Background: Mouse mammary tumor virus (MMTV), a milk-transmitted retrovirus, is considered to be involved in the development of breast tumors in mice.
Seyed Shervin Shariatpanahi, Mohammad Soleimani Darjagh, Rasoul Salehi   +2 more
doaj  

Cross-packaging of genetically distinct mouse and primate retroviral RNAs

Retrovirology, 2009
Background The mouse mammary tumor virus (MMTV) is unique from other retroviruses in having multiple viral promoters, which can be regulated by hormones in a tissue specific manner.
Jaballah Soumeya, Beebi Elizabeth, Ali Jahabar, Ghazawi Akela, Phillip Pretty, Al Dhaheri Noura, Rizvi Tahir A   +6 more
doaj   +1 more source

Targeted therapy for breast cancer prevention. [PDF]

, 2013
With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer.
Brown, Powel H, den Hollander, Petra, Savage, Michelle I   +2 more
core   +2 more sources

Lack of detection of the mouse mammary tumor-like virus (MMTV) Env gene in Iranian women breast cancer using real time PCR.

Asian Pacific Journal of Cancer Prevention, 2013
BACKGROUND Mouse mammary tumor virus (MMTV) is the major cause of mammary tumors in mice. There is limited controversial evidence about the probable etiologic role of MMTV- like virus in human breast cancer. MATERIALS AND METHODS A total of 40 Formalin
H. Tabriz, K. Zendehdel, R. Shahsiah, F. Fereidooni, Baharak Mehdipour, Z. Hosseini   +5 more
semanticscholar   +1 more source

Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor [PDF]

, 2014
Glucocorticoids are essential for life, but are also implicated in disease pathogenesis and may produce unwanted effects when given in high doses.
Alvarez, Lautaro Damian, Ashwell, Jonathan D., Burton, Gerardo, Ganesan, Sundar, Grøntved, Lars, Hager, Gordon L., Johnson, Thomas A., Levi, Valeria, Mittelstadt, Paul R., Ogara, Maria Florencia, Pecci, Adali, Pooley, John R., Presman, Diego Martin, Schiltz, R. Louis, Stortz, Martin Dario   +14 more
core   +3 more sources

Analysis of Tumor Heterogeneity and Cancer Gene Networks Using Deep Sequencing of MMTV-Induced Mouse Mammary Tumors

PLoS ONE, 2013
Cancer develops through a multistep process in which normal cells progress to malignant tumors via the evolution of their genomes as a result of the acquisition of mutations in cancer driver genes. The number, identity and mode of action of cancer driver
C. Klijn, M. Koudijs, J. Kool, J. T. ten Hoeve, M. Boer, J. de Moes, W. Akhtar, M. V. van Miltenburg, Annabel Vendel-Zwaagstra, M. Reinders, D. Adams, M. van Lohuizen, J. Hilkens, L. Wessels, J. Jonkers   +14 more
semanticscholar   +1 more source