Results 131 to 140 of about 38,824 (244)

Rapid spread of mouse mammary tumor virus in cultured human breast cells

Retrovirology, 2007
Background The role of mouse mammary tumor virus (MMTV) as a causative agent in human breast carcinogenesis has recently been the subject of renewed interest.
Günzburg Walter H, Indik Stanislav, Kulich Pavel, Salmons Brian, Rouault Francoise   +4 more
doaj   +1 more source

Cancer impacts microRNA expression, release and function in cardiac and skeletal muscle [PDF]

, 2014
Circulating microRNAs are emerging as important biomarkers of various diseases including cancer. Intriguingly, circulating levels of several microRNAs are lower in cancer patients compared with healthy individuals. In this study, we tested the hypothesis
Anjanappa, Manjushree, Bhat-Nakshatri, Poornima, Burnett, Riesa M, Chen, Daohong, Goswami, Chirayu P, Muller, William, Nakshatri, Harikrishna   +6 more
core   +1 more source

Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan

Breast Cancer Research, 2012
IntroductionThe neuron-glial antigen 2 (NG2) proteoglycan promotes pericyte recruitment and mediates pericyte interaction with endothelial cells. In the absence of NG2, blood vessel development is negatively impacted in several pathological models.
K. Gibby, W. You, K. Kadoya, Hildur R. Helgadottir, L. Young, L. Ellies, Yunchao Chang, R. Cardiff, W. Stallcup   +8 more
semanticscholar   +1 more source

Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo

Retrovirology, 2012
BackgroundBone marrow stromal cell antigen 2 (BST-2) is a cellular factor that restricts the egress of viruses such as human immunodeficiency virus (HIV-1) from the surface of infected cells, preventing infection of new cells. BST-2 is variably expressed
P. Jones, H. Mehta, Martina Maric, R. Roller, C. Okeoma   +4 more
semanticscholar   +1 more source

Comparability of Microarray Data between Amplified and Non Amplified RNA in Colorectal Carcinoma [PDF]

, 2009
Microarray analysis reaches increasing popularity during the investigation of prognostic gene clusters in oncology. The standardisation of technical procedures will be essential to compare various datasets produced by different research groups.
Brueckl, WM, Croner, RS, Dimmler, A, Hahn, EG, Hohenberger, W, Lausen, B, Papadopoulos, T, Schellerer, V, Schildberg, C, Wein, A, Zeittraeger, I   +10 more
core   +4 more sources

Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

Retrovirology, 2009
Background Mouse mammary tumor virus (MMTV) encodes the Rem protein, an HIV Rev-like protein that enhances nuclear export of unspliced viral RNA in rodent cells.
Dudley Jaquelin P, Lozano Mary M, Mertz Jennifer A   +2 more
doaj   +1 more source

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer [PDF]

, 2015
Preventing breast cancer will require the development of targeted strategies that can effectively block disease progression. Tamoxifen and aromatase inhibitors are effective in addressing estrogen receptor–positive (ER+) breast cancer development, but ...
Ambrose, Adrian, Arun, Banu K., Brady, Samuel W., Chang, Chia-Chi, Dobbs, Jessica, Ibarra-Drendall, Catherine, Jain, Shalini, Jia, Wei, Kyrish, Matt, Li, Ping, Richards-Kortum, Rebecca, Seewaldt, Victoria L., Sistrunk, Christopher, Tkaczyk, Tomasz S., Wang, Hai, Wang, Xiao, Yu, Dihua, Zhang, Qingling, Zhao, Hong   +18 more
core   +2 more sources

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors

OncoTarget, 2012
The accumulation of mutations is a contributing factor in the initiation of premalignant mammary lesions and their progression to malignancy and metastasis.
R. Callahan, U. Mudunuri, S. Bargo, A. Raafat, David McCurdy, Corinne A Boulanger, William J. Lowther, R. Stephens, B. Luke, C. Stewart, Xiaolin Wu, D. Munroe, Gilbert H. Smith   +12 more
semanticscholar   +1 more source

Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens.

PLoS Pathogens, 2006
Most inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and ...
Sanchita Bhadra, Mary M Lozano, Shelley M Payne, Jaquelin P Dudley   +3 more
doaj   +1 more source

Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. [PDF]

, 2015
Matriptase is an epithelia-specific membrane-anchored serine protease that has received considerable attention in recent years because of its consistent dysregulation in human epithelial tumours, including breast cancer.
Bergum, Christopher, Boerner, Julie, Colombo, Éloïc, Lang, Julie E, Leduc, Richard, List, Karin, Marsault, Eric, Molinolo, Alfredo A, Murray, Andrew S, Tanabe, Lauren M, Varela, Fausto A, Zoratti, Gina L   +11 more
core   +1 more source