Results 11 to 20 of about 38,824 (244)
Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice. [PDF]
PLoS ONE, 2013 Androgen receptor (AR) is commonly expressed in both the epithelium of normal mammary glands and in breast cancers. AR expression in breast cancers is independent of estrogen receptor alpha (ERα) status and is frequently associated with overexpression of
Myles C Hodgson +5 more
doaj +5 more sources
PLoS ONE, 2022 The Ubiquitin Specific Peptidase 22 (USP22), a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA) histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear.
Xianghong Kuang +5 more
doaj +4 more sources
Sequences within both the 5' UTR and Gag are required for optimal in vivo packaging and propagation of mouse mammary tumor virus (MMTV) genomic RNA. [PDF]
PLoS ONE, 2012 BACKGROUND: This study mapped regions of genomic RNA (gRNA) important for packaging and propagation of mouse mammary tumor virus (MMTV). MMTV is a type B betaretrovirus which preassembles intracellularly, a phenomenon distinct from retroviruses that ...
Farah Mustafa +7 more
doaj +2 more sources
Viruses, 2022 A Human Betaretrovirus (HBRV) has been identified in humans, dating as far back as about 4500 years ago, with a high probability of it being acquired by our species around 10,000 years ago, following a species jump from mice to humans.
G. Bevilacqua
semanticscholar +1 more source
Viruses, 2022 Human breast cancer incidence varies by geographic location. More than 20 years ago, we proposed that zoonotic transmission of the mouse mammary tumor virus (MMTV) from the western European house mouse, Mus musculus domesticus, might account for the ...
A. Stewart, Hsiao-Huei Chen
semanticscholar +1 more source
Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer
Human Vaccines & Immunotherapeutics, 2021 Breast cancer, the most frequent disease amongst women worldwide, accounts for the highest cancer-related mortality rate. Triple-negative breast cancer (TNBC) subtype encompasses ~15% of all breast cancers and lack estrogen, progesterone, and HER2 ...
I. Gupta +6 more
semanticscholar +1 more source
Pathological Features and Molecular Phenotype of MMTV Like-Positive Feline Mammary Carcinomas
Animals, 2021 In the last few years MMTV-like nucleotide sequences were detected in some feline and canine mammary tumours. Due to the confirmed role of cats in the epidemiology of the MMTV-like virus, the aim of this study was to investigate the main pathological ...
Francesca Parisi +12 more
doaj +1 more source
Pericentriolar Targeting of the Mouse Mammary Tumor Virus GAG Protein. [PDF]
PLoS ONE, 2015 The Gag protein of the mouse mammary tumor virus (MMTV) is the chief determinant of subcellular targeting. Electron microscopy studies show that MMTV Gag forms capsids within the cytoplasm and assembles as immature particles with MMTV RNA and the Y box ...
Guangzhi Zhang +7 more
doaj +1 more source
MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer [PDF]
Expert Review of Molecular Diagnostics, 2009 Mouse mammary tumor virus (MMTV) long terminal repeat (LTR)-driven transgenic mice are excellent models for breast cancer as they allow for the targeted expression of various oncogenes and growth factors in neoplastic transformation of mammary glands. Numerous MMTV-LTR-driven transgenic mouse models of breast cancer have been created in the past three ...
Pankaj, Taneja +7 more
openaire +2 more sources
Lactation defect in a widely used MMTV-Cre transgenic line of mice. [PDF]
PLoS ONE, 2011 MMTV-Cre mouse lines have played important roles in our understanding about the functions of numerous genes in mouse mammary epithelial cells during mammary gland development and tumorigenesis. However, numerous studies have not included MMTV-Cre mice as
Taichang Yuan +4 more
doaj +1 more source