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Biology of mouse mammary tumor virus (MMTV)
Cancer Letters, 1995Mouse mammary tumor viruses (MMTV) replicate in the mammary gland, appear as infectious particles in mother's milk and invade the sucking pups from the intestinal tract. The immune system is essential for MMTV in the gut to reach the mammary gland. These properties make the life cycle of MMTV unique.
A, Matsuzawa +3 more
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Breast Cancer Research and Treatment, 2000
Transgenic mice expressing c-myc and v-Ha-ras specifically in the mammary gland under the control of the mammary specific promoter MMTV develop unifocal mammary tumors with a half time of about 46 days, and these tumors express high levels of osteopontin mRNA and protein.
F, Feng, S R, Rittling
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Transgenic mice expressing c-myc and v-Ha-ras specifically in the mammary gland under the control of the mammary specific promoter MMTV develop unifocal mammary tumors with a half time of about 46 days, and these tumors express high levels of osteopontin mRNA and protein.
F, Feng, S R, Rittling
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Cancer Research, 2009
Abstract Background. Smoothened (Smo) is a key effector protein in the hedgehog signaling pathway, a developmental pathway involved in the regulation of pattern formation, proliferation, cell fate, and stem/progenitor cell function in the mammary gland.
J. Landua, R. Moraes, Y. Li, M. Lewis
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Abstract Background. Smoothened (Smo) is a key effector protein in the hedgehog signaling pathway, a developmental pathway involved in the regulation of pattern formation, proliferation, cell fate, and stem/progenitor cell function in the mammary gland.
J. Landua, R. Moraes, Y. Li, M. Lewis
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Two independent pathways for transcription from the MMTV promoter
The Journal of Steroid Biochemistry and Molecular Biology, 1994The influence of progesterone receptor (PR) and glucocorticoid receptor (GR) on transcription from the mouse mammary tumour virus (MMTV) promoter was analyzed using cell-free transcription of DNA templates with a G-free cassette. Preincubation of the templates with either PR or GR stimulates the rate of transcription initiation 10-50 fold, whereas the ...
C C, Möws +6 more
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MMTV-induced Pregnancy-dependent Mammary Tumors
Journal of Mammary Gland Biology and Neoplasia, 2008Almost 60 years ago, Foulds carefully described for the first time a particular type of mouse mammary tumor that appeared in the glands of pregnant females and disappeared shortly after delivery. Since then, the attention that researchers paid to the Mouse Mammary Tumor Virus (MMTV)-induced pregnancy-dependent tumors has not vanished through the years.
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MMTV-like env gene sequences in human breast cancer
Archives of Virology, 2001We have previously detected an MMTV env gene-like 660 bp sequence in 38% of human breast cancers, but not in normal tissues or other tumors. In this communication we report the sequences from eleven tumors and three breast cancer cell lines, and compare them to four strains of MMTV and to the known endogenous retroviral sequences.
Y, Wang +5 more
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Gene Discovery by MMTV Mediated Insertional Mutagenesis
2010Transformation of a normal cell into a cancer cell requires sequential accumulation of several genetic changes that affect various collaborating signaling cascades mainly involved in cell proliferation, survival and development [46]. To develop novel specific therapeutic compounds for cancer treatment, identification of these cancer causing genes, and ...
Annabel Vendel-Zwaagstra, John Hilkens
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The Japanese journal of experimental medicine, 1988
Expression of mouse mammary tumor virus (MMTV) antigens was observed in a wide variety of exocrine glands in adult mice by an immunoperoxidase method using rabbit antisera against gp52 and p27 of MMTV. Both exogenous and endogenous MMTV-carrying SHN, GRS/A, C3H and DDD-Mtv-2 mice expressed both antigens in the mammary, extraorbital lacrymal, urethral ...
A, Tsubura, S, Morii
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Expression of mouse mammary tumor virus (MMTV) antigens was observed in a wide variety of exocrine glands in adult mice by an immunoperoxidase method using rabbit antisera against gp52 and p27 of MMTV. Both exogenous and endogenous MMTV-carrying SHN, GRS/A, C3H and DDD-Mtv-2 mice expressed both antigens in the mammary, extraorbital lacrymal, urethral ...
A, Tsubura, S, Morii
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Endogenous MMTV Proviral Genomes in Feral Mus musculus domesticus
1986Retroviruses, unlike most viruses which are spread only as infectious agents, can also be transmitted within the germline of the host (Weiss et al. 1982). In this situation, the viral genome is passed from one generation to the next as a Mendelian genetic element within the cellular genome.
R, Callahan +3 more
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