Results 21 to 30 of about 38,824 (244)

Involvement of APOBEC3A/B Deletion in Mouse Mammary Tumor Virus (MMTV)-like Positive Human Breast Cancer

Diagnostics, 2023
The association between mouse mammary tumor virus (MMTV)-like sequences and human breast cancer (BC) is largely documented in the literature, but further research is needed to determine how they influence carcinogenesis.
Nathália de Sousa Pereira, Glauco Akelinghton Freire Vitiello, Marla Karine Amarante   +2 more
doaj   +1 more source

A human MMTV-like betaretrovirus linked to breast cancer has been present in humans at least since the copper age

Aging, 2020
The betaretrovirus Mouse Mammary Tumor Virus (MMTV) is the well characterized etiological agent of mammary tumors in mice. In contrast, the etiology of sporadic human breast cancer (BC) is unknown, but accumulating data indicate a possible viral origin ...
F. Lessi, Nicole Grandi, C. Mazzanti, Prospero Civita, C. Scatena, P. Aretini, P. Bandiera, A. Fornaciari, V. Giuffra, G. Fornaciari, A. Naccarato, E. Tramontano, G. Bevilacqua   +12 more
semanticscholar   +1 more source

Mouse Mammary Tumor Virus (MMTV)-Like env Sequence in Brazilian Breast Cancer Samples: Implications in Clinicopathological Parameters in Molecular Subtypes

International Journal of Environmental Research and Public Health, 2020
Background: Breast cancer (BC) is a complex disease in which susceptibility and clinical course depend on multiple factors. Evidence suggests that a mouse mammary tumor virus (MMTV)-homolog may be present in human BCs; however, little is known about its ...
Nathália de Sousa Pereira, Glauco Akelinghton Freire Vitiello, Bruna Karina Banin-Hirata, Glaura Scantamburlo Alves Fernandes, Maria José Sparça Salles, Marla Karine Amarante, Maria Angelica Ehara Watanabe   +6 more
semanticscholar   +1 more source

Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10−/− mouse model of inflammatory bowel disease

Microbiome, 2023
Background Following viral infection, genetically manipulated mice lacking immunoregulatory function may develop colitis and dysbiosis in a strain-specific fashion that serves as a model for inflammatory bowel disease (IBD).
Heather Armstrong, Mandana Rahbari, Heekuk Park, David Sharon, Aducio Thiesen, Naomi Hotte, Ning Sun, Hussain Syed, Hiatem Abofayed, Weiwei Wang, Karen Madsen, Eytan Wine, Andrew Mason   +12 more
doaj   +1 more source

Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARα agonist AM580 [PDF]

Oncogene, 2010
We hypothesized that specific activation of a single retinoic acid receptor-alpha (RARalpha), without direct and concurrent activation of RARbeta and gamma, will inhibit mammary tumor oncogenesis in murine models relevant to human cancer. A total of 50 uniparous mouse mammary tumor virus (MMTV)-neu and 50 nuliparous MMTV-wnt1 transgenic mice were ...
Lu, Yongke, Bertran, Silvina, Samuels, Tracey-Ann, Mira-y-Lopez, Rafael, Farias, Eduardo   +4 more
openaire   +2 more sources

Decoding the mystery of MMTV-like virus and its relationship with breast cancer metastasis

Journal of Infection and Public Health, 2023
Background: MMTV causes mammary tumors in mice, and it is associated with invasive and aggressive forms of breast cancer in humans. However, the underlying mechanisms are yet unknown.
Hafiz Fawad Khalid, Sadia Bibi, Amjad Ali, Nida Fawad, Muhammad Usman Shams, Wafa Idrees, Muhammad Waqas, Shazia Rafique, Abbas khan, Faizullah Khan, Fahad Nasser Almajhdi   +10 more
doaj   +1 more source

Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]

, 2015
Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim, Andradas, Clara, Arnold, Norbert, Artola, Marta, Bauer, Maret, Blasco-Benito, Sandra, Bronsert, Peter, Caffarel, María M., Canela, Enric I., Fernández-Piqueras, José, Flores, Juana M., García-Taboada, Elena, Guzmán, Manuel, Hamann, Sigrid, Klapper, Wolfram, Martín-Villar, Ester, McCormick, Peter J., Megías, Diego, Moreno, Estefanía, Moreno-Bueno, Gema, Ortega-Gutiérrez, Silvia, Pérez-Gómez, Eduardo, Pérez-Martínez, Manuel, Quintanilla, Miguel, Röcken, Christoph, Soriano, Joaquim, Staebler, Annette, Stickeler, Elmar, Sánchez, Cristina, Villa-Morales, María, Vázquez-Villa, Henar, Wenners, Antonia   +31 more
core   +1 more source

Prevalence of HPV, EBV, MMTV and SV40 co-infection in women with invasive breast cancer: as a potential new viral etiology [PDF]

Exploration of Medicine
Aim: Breast cancer (BC) is the leading cause of female cancer-related death worldwide. The high incidence of BC has sparked interest in the viral agents role in its development.
Kaoutar Anouar Tadlaoui, Amal Souiri, Soukayna Alaoui Sosse, Kawtar Nabil, Mustapha Benhessou, Moulay Mustapha Ennaji   +5 more
doaj   +1 more source

Wnt5a suppresses tumor formation and redirects tumor phenotype in MMTV-Wnt1 tumors. [PDF]

PLoS ONE, 2014
Wnt5a is a non-canonical signaling Wnt that has been implicated in tumor suppression. We previously showed that loss of Wnt5a in MMTV-PyVmT tumors resulted in a switch in tumor phenotype resulting in tumors with increased basal phenotype and high Wnt/β ...
Stephanie L Easter, Elizabeth H Mitchell, Sarah E Baxley, Renee Desmond, Andra R Frost, Rosa Serra   +5 more
doaj   +1 more source

The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells. [PDF]

, 2014
BackgroundIdentification and characterization of molecular controls that regulate mammary stem and progenitor cell homeostasis are critical to our understanding of normal mammary gland development and its pathology.ResultsWe demonstrate that conditional ...
Band, Hamid, Band, Vimla, Edwards, Emily, Kopp, Janel L, Malhotra, Gautam K, Naramura, Mayumi, Sander, Maike, Zhao, Xiangshan   +7 more
core   +2 more sources