Results 51 to 60 of about 38,824 (244)

Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype

BMC Medicine, 2004
Background MMTV-Wnt1 transgenic mice develop mammary hyperplasia early in development, followed by the appearance of solitary mammary tumors with a high proportion of cells expressing early lineage markers and many myoepithelial cells.
Li Yi, Podsypanina Katrina, Varmus Harold E   +2 more
doaj   +1 more source

Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes [PDF]

, 2006
ISWI proteins form the catalytic core of a subset of ATP-dependent chromatin remodelling activities in eukaryotes from yeast to man. Many of these complexes have been found to reposition nucleosomes, but with different directionalities.
Alen, Beard, Becker, Brehm, Bruno, Bruno, Davey, Dillingham, Drew, Eberharter, Elfring, Fazzio, Flaus, Flaus, Flaus, Hamiche, Kagalwala, Kang, Kassabov, Langst, Lorch, Lowary, Luger, Lusser, Meersseman, Mizuguchi, Morillon, Rigaut, Schnitzler, Tran, Tsukiyama, Tsukiyama, Vary, Zofall   +33 more
core   +4 more sources

Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer [PDF]

, 2020
Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response.
Chervoneva, Inna, Davis, Rachel, Gorenstein, David G, Hasan, Nafis, Hills, Natalie, Ichimura, Norihisa, Kameyama, Hiroyasu, Kondo, Yuji, Leslie, Macall, Lokesh, Ganesh L R, Morita, Yoshihiro, Rui, Hallgeir, Tanaka, Takemi, Volk, David E, Zhang, Roy   +14 more
core   +3 more sources

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model

Cell Communication and Signaling, 2018
The small GTPase Arf6 and its downstream effector AMAP1 (also called ASAP1/DDEF1) constitute a signaling pathway promoting cell invasion, in which AMAP1 interacts with several different proteins, including PRKD2, EPB41L5, paxillin, and cortactin ...
Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, S. Hashimoto, Haruka Handa, H. Yamamoto, A. Hashimoto, H. Sabe   +7 more
semanticscholar   +1 more source

Downregulation of Muc1 in MMTV-c-Neu tumors [PDF]

Oncogene, 2004
MUC1 is a tumor antigen, overexpressed in approximately 90% of human breast cancers. In normal glandular epithelia, MUC1 is expressed at the apical surface; however, in carcinomas an aberrantly glycosylated form of MUC1 is upregulated and expressed around the entire surface of the cell. Previously, we have shown that a lack of Muc1 significantly delays
Melissa C, Adriance, Sandra J, Gendler
openaire   +2 more sources

Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model

BMC Genomics, 2017
BackgroundMalignant breast cancer with complex molecular mechanisms of progression and metastasis remains a leading cause of death in women. To improve diagnosis and drug development, it is critical to identify panels of genes and molecular pathways ...
Ying Cai, Rubén Nogales-Cadenas, Quanwei Zhang, Jhih-rong Lin, Wen Zhang, K. O’Brien, C. Montagna, Zhengdong D. Zhang   +7 more
semanticscholar   +1 more source

Breast Cancer Promotes Cardiac Dysfunction Through Deregulation of Cardiomyocyte Ca2+‐Handling Protein Expression That is Not Reversed by Exercise Training

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Patients treated for breast cancer have a high incidence of cardiovascular complications. In this study, we evaluated the impact of breast cancer on cardiac function and cardiomyocyte Ca2+‐handling protein expression.
Tassia S. R. da Costa, Ursula Urias, Marcelo V. Negrao, Camila P. Jordão, Clévia S. Passos, Igor L. Gomes‐Santos, Vera Maria C. Salemi, Anamaria A. Camargo, Patricia C. Brum, Edilamar M. Oliveira, Ludhmila A. Hajjar, Roger Chammas, Roberto K. Filho, Carlos E. Negrao   +13 more
doaj   +1 more source

Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo [PDF]

, 2017
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030000) and the CAS-Novonordisk Foundation, as well as grants from the ‘1000 talents’ recruitment program, and a ‘Great-wall professorship’ from ...
Jin, Wanzhu, Król, Elżbieta, Li, Baoguo, Li, Li, Li, Min, Li, Ting, Niu, Chaoqun, Speakman, John R., Wang, Guanlin   +8 more
core   +2 more sources

Exogenous Mouse Mammary Tumor Virus (MMTV) Infection Induces Endogenous MMTVsagExpression

Virology, 1996
The mouse mammary tumor virus (MMTV) superantigen (Sag) protein is involved in the transmission of milk-borne MMTV from virus-infected milk in the gut to the target mammary gland tissue. Using an RT-PCR assay for in vivo MMTV infection, BALB/c or C3H mice nursed on C3H MMTV-infected mothers showed sag mRNA expression in intestine, spleen, and thymus as
XU, LI, WRONA, THOMAS J., DUDLEY, JAQUELIN P.   +2 more
openaire   +2 more sources

Does mouse mammary tumor-like virus cause human breast cancer? Applying Bradford Hill criteria postulates

Bulletin of the National Research Centre, 2020
Background The role of mouse mammary tumor-like virus (MMTV-like virus) in human breast cancer (BC) has already been widely investigated worldwide with conflicting results.
Yasir Hameed, Muhammad Usman, Mukhtiar Ahmad   +2 more
doaj   +1 more source