Results 51 to 60 of about 1,239,384 (284)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral Lagrangians for spin-$\frac{1}{2}$ and spin-$\frac{3}{2}$ doubly charmed baryons

Physical Review, 2023
The relativistic chiral Lagrangians for both spin-12 and spin-32 doubly charmed baryons are constructed up to the order O(p4). From O(p2) to O(p4), there are 19, 74, and 452 independent terms in the two-flavor case and 25, 112, and 864 independent terms in the three-flavor case. The chiral Lagrangians in the heavy diquark limit are also obtained.
Liu, Hao, Zou, Yuan-He, Liu, Yan-Rui, Jiang, Shao-Zhou   +3 more
openaire  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Optimalisasi Karbon Aktif Berbasis Bonggol Jagung untuk Pengelolaan Limbah Logam Berat Pb dan Mn

Jurnal Ilmu Lingkungan
Pencemaran lingkungan oleh limbah logam berat, seperti timbal (Pb) dan mangan (Mn), merupakan isu krusial yang berdampak signifikan pada ekosistem dan kesehatan manusia. Untuk mengatasi masalah ini, penelitian ini bertujuan untuk mengoptimalkan pembuatan
Nisya Indriyanti Irawan, Reny Afifah, Ainun Nadira, Suparno Suparno   +3 more
doaj   +1 more source

PET imaging of [ 52 Mn]Mn-DOTATATE and [ 52 Mn]Mn-DOTA-JR11

Abstract Manganese-52 is gaining interest as an isotope for PET imaging due to its desirable decay and chemical properties for radiopharmaceutical development. Somatostatin receptor 2 (SSTR2) is significantly overexpressed by neuroendocrine tumors (NETs) and is an important target for nuclear imaging and therapy.
Omweri, James M., Houson, Hailey A., Lynch, Shannon E., Tekin, Volkan, Sorace, Anna G., Lapi, Suzanne E.   +5 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Evaluation of Route Optimization Method in Mobile IPv6 Networks

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2019
With Mobile IPv6 (MIPv6) protocol support, a host can move from its homenetwork or one network to another. Tunneling and delay due to rectangularrouting are one of the key factors of optimizing a route from CorrespondentNode (CN) to Mobile Node (MN ...
Cemal Koçak, Mohamedi M. Mjahıdı
doaj  

Knowledge, Attitudes, and Practices of Postoperative Pain Management by Nurses in Selected District Hospitals in Ghana

SAGE Open Nursing, 2018
Introduction There is documented evidence pointing to the fact that there are numerous challenges with postoperative pain (POP) management globally. However, these challenges with POP management are more profound in developing countries.
Awube Menlah MN, Isabella Garti MN, Sarah Ama Amoo MN, Confidence Alorse Atakro MN, Caleb Amponsah BSc, Dorcas Frempomaa Agyare MN   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source