Results 71 to 80 of about 991,080 (294)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mn-Doped g‑C₃N₄ Nanoribbon for Efficient Visible-Light Photocatalytic Water Splitting Coupling with Methylene Blue Degradation [PDF]

, 2018
The photocatalysis of water-splitting coupling with pollutant degradation was achieved on Mn-doped g-C3N4 nanoribbon (Mn-CNNR) with double purposes of environmental protection and renewable energy production.
Zhongjun Li (322364), Ji-Chao Wang (1411894), Yuping Zhang (136067), Qian-Qian Kong (5362226), Lingbo Qu (699449), Cheng-Xing Cui (1630150), Chun-Yu Ren (5362229), Kai Jiang (220274)   +7 more
core   +1 more source

The behaviour of Mn in amphiboles: Mn in richterite

European Journal of Mineralogy, 1993
The crystal structures and site occupancies of 5 manganoan richterites have been refined to R indices ≤ 2% using single-crystal MoKα X-ray diffraction data. For all these amphiboles, EMP analyses indicate significant occupancy of the M(4) site by (Mn 2+ , Fe 2+ , Mg).
Roberta Oberti, Frank C. Hawthorne, Luciano Ungaretti, Cannillo Cnr   +3 more
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Mn-Mediated Electrochemical Trifluoromethylation/C(sp²)–H Functionalization Cascade for the Synthesis of Azaheterocycles [PDF]

, 2019
A general electrohemical strategy for the combined trifluoromethylation/C­(sp2)–H functionalization using Langlois’ reagent as the CF3 source under oxidant-free conditions was developed.
Feng Li (30515), Lei Zhang (38117), Guangcan Bai (6255854), Zhenxing Zhang (1717153), Fanyang Mo (1372980), Yang Yang (45629), Yang Cao (53545), Guoquan Liu (1787437)   +7 more
core   +1 more source

MAIN CAUSES THAT AFFECT THE QUALIFICATION OF BUSINESS MANAGEMENT ENGINEERING STUDENTS IN THE TECNOLOGICO NACIONAL DE MEXICO/INSTITUTO TECNOLOGICO DE SAN LUIS POTOSI

Ra Ximhai, 2020
The degree index is an indicator that assesses the quality of a higher-level educational institution. At the Instituto Tecnológico de San Luis Potosí, the value of the degree index is 6%, AD2012-EJ2017 generation, for the Business Management Engineering ...
María Eugenia Navarrete-Sánchez, Ma. Dolores Delgado-Celis, María Leonor Rosales-Escobar   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Modeling the deformation textures and microstructural evolutions of a Fe–Mn–C TWIP steel during tensile and shear testing [PDF]

, 2012
The high manganese austenitic steels with low stacking fault energy (SFE) present outstanding mechanical properties due to the occurrence of two strain mechanisms: dislocation glide and twinning. Both mechanisms are anisotropic.
Barbier, David, Bolle, Bernard, FAVIER, Véronique, BARBIER, D, BOLLE, B   +4 more
core   +1 more source