Results 71 to 80 of about 2,908,064 (273)

MN 001

Drugs in R & D, 2007
MN 001 is an orally bioavailable anti-inflammatory agent, originated by Kyorin Pharmaceutical, which is being developed in clinical trials by the US company MediciNova for the treatment of interstitial cystitis and asthma. Kyorin is developing the drug as KCA 757 for these indications.
openaire   +2 more sources

Orbital polarons and ferromagnetic insulators in manganites

, 2000
We argue that in lightly hole doped perovskite-type Mn oxides the holes (Mn$^{4+}$ sites) are surrounded by nearest neighbor Mn$^{3+}$ sites in which the occupied $3d$ orbitals have their lobes directed towards the central hole (Mn$^{4+}$) site and with ...
A. E. Bocquet, A. J. Millis, A. Lanzara, A. Moreo, A. Urushibara, D. Arovas, D. I. Khomskii, G. A. Sawatzky, H. Yoshizawa, J. B. Goodenough, J. B. Goodenough, J. M. De Teresa, J. van den Brink, K. Kubo, M. Fäth, M. Uehara, M. Yu. Kagan, N. Furukawa, P. Mahadevan, R. Kilian, T. Mizokawa, T. Mizokawa, T. Mizokawa, T. Mizokawa, T. Mizokawa, V. I. Anisimov, W. A. Harrison, Y. Endoh, Y. Tomioka, Y. Yamada, Z. Jirak   +30 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Abortion - a philosophical perspective

Curationis, 2001
The central issue in the abortion debate is the moral status of the conceptus. There are two positions that argue this issue. At one extreme are the views of the pro-life group which argues that human life begins at the moment of conception whilst at the
MN Jali
doaj   +1 more source

Electronic structure and exchange constants in magnetic semiconductors digital alloys: chemical and band-gap effects

, 2006
First-principles simulations have been performed for [001]-ordered Mn/Ge and Mn/GaAs "digital alloys", focusing on the effects of i) a larger band-gap and ii) a different semiconducting host on the electronic structure of the magnetic semiconductors of ...
Anisimov, Chen, Cho, Continenza, Cubiotti, Dietl, Johnston-Halperin, Kong, Lezaic, Li, Mac Donald, Mahadevan, Mermin, Monkhorst, Ottaviano, Park, Perdew, Picozzi, Picozzi, Sandratskii, Shick, Soo, Stroppa, Weng, Wimmer, Zhao, Zhao   +26 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Ekonomi Sharî‘ah dan Ketidakadilan Kapitalisme Global

Islamica: Jurnal Studi Keislaman, 2014
This paper understands that the Sharî‘ah Economics is a serious contender for the modern global capitalistic economic system. Capitalism has been responsible for the collapse of not only the global economic system but also the moral deterioration of ...
MN Harisudin
doaj   +1 more source

Towards an archaeology of media ecologies : the case of Italian free radios [PDF]

, 2011
This article looks at the contemporary reinvention of the term Media Ecologies in the work of Matthew Fuller, arguing that its provenance is less form Postman's Media Ecology Association andmore form the work of Felix Guattari.
Goddard, MN
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source