Results 111 to 120 of about 9,323 (234)

Prevalence of Colonization, Association With Disease Stage and Effect of Eradication of Staphylococcus aureus in Cutaneous T‐Cell Lymphoma: A Systematic Review and Meta‐Analysis

JEADV Clinical Practice, Volume 5, Issue 3, Page 810-820, September 2026.
ABSTRACT Background Cutaneous T‐cell lymphoma (CTCL) is a rare and heterogeneous group of skin‐homing lymphomas with a largely unknown pathogenesis. Staphylococcus aureus (S. aureus) colonization has been implicated in exacerbating CTCL, particularly in advanced stages. Objectives This study assessed the prevalence of S.
Ida Lind Holm, Sarah Søltoft Rasmussen, Somaia Naassan, Misbah N. Ghazanfar, Kenneth Thomsen, Rikke Bech, Lise M. Lindahl, Maria Kamstrup, Simon Francis Thomsen, Zarqa Ali   +9 more
wiley   +1 more source

A novel synthetic nucleic acid mixture for quantification of microbes by mNGS

Microbial Genomics
Metagenomic next-generation sequencing (mNGS) provides considerable advantages in identifying emerging and re-emerging, difficult-to-detect and co-infected pathogens; however, the clinical application of mNGS remains limited primarily due to the lack of quantitative capabilities.
Hailing Wanghu, Yingzhen Li, Jin Huang, Kangze Pu, Fengming Guo, Peiwen Zhong, Ting Wang, Jianying Yuan, Yan Yu, Jiachang Chen, Jun Liu, Jason J. Chen, Chaohui Hu   +12 more
openaire   +2 more sources

Integrative In Silico Profiling of Major Phytochemicals From a Sclerocarya birrea–Nauclea latifolia–Piper longum Mixture: Docking, Molecular Dynamics, ADMET, and Ligand‐Based Target Prediction on Shared Pathways in Type 2 Diabetes Mellitus and Alzheimer's Disease

ChemistryOpen, Volume 15, Issue 9, September 2026.
Which major phytochemical from the Sclerocarya birrea–Nauclea latifolia–Piper longum mixture engages shared targets across the T2DM–AD axis? Integrated docking, triplicate 100‐ns molecular dynamics, post‐MD MM‐GBSA, and ADMET/target prediction prioritize QR‐PME, which forms stable GSK3β and TACE complexes with binding energy estimates comparable to ...
Jean Philippe Djientcheu Tientcheu, Erman Salih İstifli   +1 more
wiley   +1 more source

Clinical Value of Metagenomic Next‐Generation Sequencing Versus Conventional Methods in Diagnosing Cryptococcal Infection After Kidney Transplantation

Organ Medicine, Volume 3, Issue 3, Page 130-138, September 2026.
This retrospective study evaluated metagenomic next‑generation sequencing (mNGS) against conventional methods (India ink, culture, antigen) for diagnosing cryptococcal infection in 16 kidney transplant recipients. mNGS showed a significantly higher positivity rate (93.8% vs 62.5%, p = 0.031) and shorter turnaround time (24 vs. 120 h, p < 0.001).
Luhao Liu, Rongxin Chen, Haonan Lin, Yuhe Guo, Guanghui Li, Jiali Fang, Zheng Chen   +6 more
wiley   +1 more source

Clinical Characteristics and Predicting Disease Severity in Chlamydia psittaci Infection Based on Metagenomic Next-Generation Sequencing

Infection and Drug Resistance
Mingzhu Huang,1– 3 Yuefeng Wang,1,4 Yun Lu,1,5 Wenxin Qu,1 Qianda Zou,1 Dan Zhang,1– 3 Yifei Shen,1– 3 Dongsheng Han,1– 3 Fei Yu,1– 3 Shufa Zheng1– 3 1Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University School of ...
Huang M, Wang Y, Lu Y, Qu W, Zou Q, Zhang D, Shen Y, Han D, Yu F, Zheng S   +9 more
doaj  

Central Nervous System Aspergillosis: Advances in Diagnosis, Therapeutics, and Multidisciplinary Management (2026 Update)

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Background Central nervous system (CNS) aspergillosis is a life‐threatening infection with mortality rates exceeding 50%, especially in immunocompromised patients. Significant challenges persist due to limited antifungal drug penetration into the CNS, emerging resistance, and diagnostic delays, despite advancements in therapy and diagnostics ...
Moustafa A. Mansour, Mohamed Wahid, Mohamed A. S. El Molla, Mohamed H. Helmy, Taha Mohammed Adel, Hamdi Nabawi Mostafa   +5 more
wiley   +1 more source

Complementary mNGS and traditional testing for bloodstream infections

Open Medicine
Abstract Bloodstream infections (BSIs) require rapid and accurate etiological diagnosis to guide timely antimicrobial therapy. Conventional diagnostic approaches, particularly blood culture, remain indispensable for antimicrobial susceptibility testing; however, they are limited by prolonged turnaround time and reduced sensitivity ...
Dongjuan Chen, Xuemei Li, Zhenhui Wang, Liping Huang, Liu Qin   +4 more
openaire   +1 more source

Bacteriophage combined with mNGS enhances the specificity of bacterial infection diagnosis

Journal of Infection
Metagenomic next-generation sequencing (mNGS) is an important tool for enhancing pathogen detection in infected patients. However, distinguishing between specimens that are infected or colonized is still a major challenge.To explore the composition of bacteriophages in the blood and respiratory tract of the human body, the association between ...
Ying Liu, Yafeng Zheng, Lu Wang, Yuxin Guo, Guangyun Huang, Zhiyong Yuan, Fuhua Wang, Wei Gai, Jinyan Xing   +8 more
openaire   +2 more sources

Utility of paired plasma and drainage fluid mNGS in diagnosing acute intra-abdominal infections with sepsis

Background Metagenomic next-generation sequencing (mNGS) has been increasingly applied in sepsis. We aimed to evaluate the diagnostic and therapeutic utility of mNGS of paired plasma and peritoneal drainage (PD) fluid samples in comparison to culture ...
Qi-wen Yang, Dong Zhang, Jia-yu Mao, Yun Long, Na Cui, Dong-kai Li   +5 more
core   +1 more source

How to fight poverty: Invite MNGs to exploit

, 2018
Economy
openaire   +2 more sources