Results 21 to 30 of about 410,012 (337)

Microbial defenses against mobile genetic elements and viruses: Who defends whom from what?

PLoS Biology, 2022
Prokaryotes have numerous mobile genetic elements (MGEs) that mediate horizontal gene transfer (HGT) between cells. These elements can be costly, even deadly, and cells use numerous defense systems to filter, control, or inactivate them.
E. Rocha, David Bikard
semanticscholar   +1 more source

The defense island repertoire of the Escherichia coli pan-genome.

PLoS Genetics, 2023
It has become clear in recent years that anti-phage defense systems cluster non-randomly within bacterial genomes in so-called "defense islands". Despite serving as a valuable tool for the discovery of novel defense systems, the nature and distribution ...
Dina Hochhauser, Adi Millman, Rotem Sorek   +2 more
doaj   +1 more source

Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM

Nature Communications, 2022
The mobile resistance gene bla _NDM encodes the NDM enzyme which hydrolyses carbapenems, a class of antibiotics used to treat some of the most severe bacterial infections.
M. Acman, Ruobing Wang, L. van Dorp, L. Shaw, Qi Wang, Nina Luhmann, Yuyao Yin, Shijun Sun, Hongbin Chen, Hui Wang, F. Balloux   +10 more
semanticscholar   +1 more source

Mobile genetic elements – mechanism and consequences of transposition

Journal of Education, Health and Sport, 2017
Retrotransposons represent a significant part of the genome in eukaryote organisms. With DNA transposons, they belong to mobile genetic elements. There are two classes of transposons, DNA transposons and retrotransposons.
Mateusz Wędrowski, Paweł Waśniowski, Ewelina Wędrowska, Joanna Golińska, Elżbieta Piskorska, Walery Żukow   +5 more
doaj   +3 more sources

Meeting report: transposable elements at the crossroads of evolution, health and disease 2023

Mobile DNA, 2023
The conference “Transposable Elements at the Crossroads of Evolution, Health and Disease” was hosted by Keystone Symposia in Whistler, British Columbia, Canada, on September 3–6, 2023, and was organized by Kathleen Burns, Harmit Malik and Irina Arkhipova.
Irina R. Arkhipova, Kathleen H. Burns, Katherine B. Chiappinelli, Edward B. Chuong, Clement Goubert, Alba Guarné, Amanda M. Larracuente, E. Alice Lee, Henry L. Levin   +8 more
doaj   +1 more source

CRISPR–Cas in mobile genetic elements: counter-defence and beyond

Nature Reviews Microbiology, 2019
Guilhem Faure, Sergey A. Shmakov, Winston X. Yan, David R. Cheng, David A. Scott, J. E. Peters, K. Makarova, E. Koonin   +7 more
semanticscholar   +3 more sources

Detection of mobile genetic elements associated with antibiotic resistance in Salmonella enterica using a newly developed web tool: MobileElementFinder

Journal of Antimicrobial Chemotherapy, 2020
Objectives Antimicrobial resistance (AMR) in clinically relevant bacteria is a growing threat to public health globally. In these bacteria, antimicrobial resistance genes are often associated with mobile genetic elements (MGEs), which promote their ...
M. Johansson, Valeria Bortolaia, Supathep Tansirichaiya, F. Aarestrup, A. Roberts, T. Petersen   +5 more
semanticscholar   +1 more source

Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome

Nature Communications, 2022
Mobile genetic elements (MGEs) carrying antibiotic resistance genes (ARGs) disseminate ARGs when they mobilise into new bacterial hosts. The nature of such horizontal gene transfer (HGT) events between human gut commensals and pathogens remain poorly ...
S. Forster, Jun Liu, Nitin Kumar, E. Gulliver, J. Gould, Alejandra Escobar-Zepeda, T. Mkandawire, Lindsay J. Pike, Y. Shao, Mark D. Stares, H. Browne, B. Neville, T. Lawley   +12 more
semanticscholar   +1 more source

Mobile Genetic Elements in Streptococci [PDF]

Current Issues in Molecular Biology, 2019
Streptococci are a group of Gram-positive bacteria belonging to the family Streptococcaceae, which are responsible of multiple diseases. Some of these species can cause invasive infection that may result in life-threatening illness. Moreover, antibiotic-resistant bacteria are considerably increasing, thus imposing a global consideration.
Lu, Miao, Gong, Tao, Zhang, Anqi, Tang, Boyu, Chen, Jiamin, Zhang, Zhong, Li, Yuqing, Zhou, Xuedong   +7 more
openaire   +2 more sources

Long-read metagenomic sequencing reveals shifts in associations of antibiotic resistance genes with mobile genetic elements from sewage to activated sludge

Microbiome, 2022
There is concern that the microbially rich activated sludge environment of wastewater treatment plants (WWTPs) may contribute to the dissemination of antibiotic resistance genes (ARGs). We applied long-read (nanopore) sequencing to profile ARGs and their
D. Dai, Connor L. Brown, H. Bürgmann, D. Larsson, I. Nambi, Tong Zhang, Carl-Fredrik Flach, A. Pruden, P. Vikesland   +8 more
semanticscholar   +1 more source