Results 41 to 50 of about 37,102 (308)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A machine-learning approach to a mobility policy proposal
Heliyon, 2023 The objective of the URBANITE project is to design an open-data, open-source, smart-city framework to enhance the decision-making processes in European cities. The framework's basis is a robust and user-friendly simulation tool that is supplemented with several innovative service modules.
Shulajkovska, Miljana +3 more
openaire +4 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Advanced Engineering Research, 2018 Introduction. Issues on the functional unification of the adaptive hydraulic drive module are studied. For the first time, self-adapting mechanisms are considered taking into account adaptive intercommunication of the load control ...
V. A. Pershin, T. A. Khinikadze
doaj +1 more source
An integrated process–machine approach for designing productive and lightweight milling machines [PDF]
, 2011 This paper provides an integrated approach for designing large milling machines, taking both mass reduction of mobile structural components and the maximum material removal rate into account. This approach considers a representative milling operation and
J.J. Zulaika +5 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Evolution of machine intelligence for mobile robot.
Journal of the Robotics Society of Japan, 1988 Active research and development is carried out for various mobile robots or robotic vehicles. This paper tries to find a new principle of the evolution of machine intelligence for robotic vehicles. The machine intelligence of robotic vehicles is the integrated ability composed of sensors, actuators, and computers, which produces the travel versatility ...
openaire +2 more sources
Ants: Mobile Finite State Machines
CoRR, 2013 Consider the Ants Nearby Treasure Search (ANTS) problem introduced by Feinerman, Korman, Lotker, and Sereni (PODC 2012), where $n$ mobile agents, initially placed at the origin of an infinite grid, collaboratively search for an adversarially hidden treasure. In this paper, the model of Feinerman et al.
Yuval Emek +3 more
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source