Results 51 to 60 of about 68,518 (254)
Biomedicines, 2023 Retrotransposons have played an important role in evolution through their transposable activity. The largest and the only currently active human group of mobile DNAs are the LINE-1 retrotransposons.
Fadi Touma +5 more
doaj +1 more source
Estrogen receptor mRNA in mineralized tissues of rainbow trout: calcium mobilization by estrogen
FEBS Letters, 1997 RT‐PCR was undertaken on total RNA extracts from bone and scales of the rainbow trout, Oncorhynchus mykiss. The rainbow trout estrogen receptor (ER)‐specific primers used amplified a single product of expected size from each tissue which, using Southern blotting, strongly hybridized with a 32P‐labelled rtER probe under stringent conditions.
K J, Armour +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Self-Reported and Physiologic Reactions to Third BNT162b2 mRNA COVID-19 (Booster) Vaccine Dose
Emerging Infectious Diseases, 2022 Despite extensive technological advances in recent years, objective and continuous assessment of physiologic measures after vaccination is rarely performed.
Merav Mofaz +7 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Rapid mitochondrial genome evolution through invasion of mobile elements in two closely related species of arbuscular mycorrhizal fungi. [PDF]
PLoS ONE, 2013 Arbuscular mycorrhizal fungi (AMF) are common and important plant symbionts. They have coenocytic hyphae and form multinucleated spores. The nuclear genome of AMF is polymorphic and its organization is not well understood, which makes the development of ...
Denis Beaudet +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism [PDF]
Brazilian Journal of Medical and Biological Research, 2014 Our aim was to investigate the role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism. Coronary angiography and intravascular ultrasound (IVUS) were performed in 60 stable angina pectoris ...
Z.X. Zhong +11 more
doaj +3 more sources
Phloem-mobile messenger RNAs and root development
Frontiers in Plant Science, 2013 Numerous signal molecules move through the phloem to regulate development, including proteins, secondary metabolites, small RNAs and full-length transcripts.
David J. Hannapel +2 more
doaj +1 more source
(Don’t) Look Up!: Is short-root just a short‐root plant?
Frontiers in Plant Science, 2022 SHORT-ROOT (SHR) is a mobile transcription factor that plays important roles in ground tissue patterning, stem cell niche specification and maintenance, and vascular development in Arabidopsis roots.
Eun Kyung Yoon, Jiyeong Oh, Jun Lim
doaj +1 more source