Results 51 to 60 of about 125,603 (298)

Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [PDF]

, 2020
Background Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...
Aramburu, Ana, Bhatia, Vaibhav, Bhattacharya, Shom S, Calado, Sofia, Chakarova, Christina, de la Cerda, Berta, Diez-Lloret, Andrea, Díaz-Corrales, Francisco J, García-Delgado, Ana B, Massalini, Simone, Montero-Sánchez, Adoración, Rodríguez-Bocanegra, Eduardo, Rodríguez-Martínez, Daniel, Valdés-Sánchez, Lourdes   +13 more
core   +2 more sources

4G mobile phone radiation alters some immunogenic and vascular gene expressions, and gross and microscopic and biochemical parameters in the chick embryo model

Veterinary Medicine and Science, 2023
Background The risks to human health have grown over the past 10 years due to the excessive use of mobile phones. Objectives The study was designed to determine the harmful effects of 4G mobile phone radiation on the expression of immunogenic and ...
Md. Sadequl Islam, Md. Mominul Islam, Md. Moshiur Rahman, Khaleda Islam   +3 more
doaj   +1 more source

VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners

Life, 2021
The United States has a rich history of mining including uranium (U)-mining, coal mining, and other metal mining. Cardiovascular diseases (CVD) are largely understudied in miners and recent literature suggests that when compared to non-U miners, U-miners
Nour A. Ass’ad, Xin Shore, Orrin Myers, Alexandra R. Camacho, Quiteria Jacquez, Charles Pollard, Linda S. Cook, Shuguang Leng, Kimberly Page, Akshay Sood, Katherine E. Zychowski   +10 more
doaj   +1 more source

Re-analysis of mobile mRNA datasets highlights challenges in the detection of mobile transcripts from short-read RNA-Seq data

AbstractShort-read RNA-Seq analyses of grafted plants have led to the proposal that large numbers of mRNAs move over long distances between plant tissues, acting as potential signals. The detection of transported transcripts by RNA-Seq is both experimentally and computationally challenging, requiring successful grafting, delicate harvesting, rigorous ...
Paajanen P, Tomkins M, Hoerbst F, Veevers R, Heeney M, Thomas HR, Apelt F, Saplaoura E, Gupta S, Frank M, Walther D, Faulkner C, Kehr J, Kragler F, Morris RJ.   +14 more
europepmc   +2 more sources

Towards molecular systems biology of gene transcription and regulation [PDF]

, 2010
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Cramer, Patrick
core   +1 more source

SCIFER: approach for analysis of LINE-1 mRNA expression in single cells at a single locus resolution

Mobile DNA, 2022
Background Endogenous expression of L1 mRNA is the first step in an L1-initiated mutagenesis event. However, the contribution of individual cell types to patterns of organ-specific L1 mRNA expression remains poorly understood, especially at single-locus ...
Emily C. Stow, Melody Baddoo, Alexis J. LaRosa, Dawn LaCoste, Prescott Deininger, Victoria Belancio   +5 more
doaj   +1 more source

Interactions of the Streptococcus pneumoniae Toxin-Antitoxin RelBE Proteins with Their Target DNA

Microorganisms, 2021
Type II bacterial toxin-antitoxin (TA) systems are found in most bacteria, archaea, and mobile genetic elements. TAs are usually found as a bi-cistronic operon composed of an unstable antitoxin and a stable toxin that targets crucial cellular functions ...
Inmaculada Moreno-Córdoba, Wai-Ting Chan, Concha Nieto, Manuel Espinosa   +3 more
doaj   +1 more source

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]

, 2017
Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi, Gao, Yue, Han, Jiayin, La Frano, Michael R, Li, Chunying, Li, Guiqin, Li, Xiaolong, Liang, Aihua, Liu, Jing, Newman, John W, Pan, Chen, Tian, Jingzhuo, Wang, Lianmei, Xiang, Shixie, Yi, Yan, Zhang, Yushi, Zhao, Yong, Zhu, Jingjing   +17 more
core   +2 more sources

Impact of GSM-EMW exposure on the markers of oxidative stress in fetal rat liver

Scientific Reports, 2023
The current study investigated the effects of 24 h/day prenatal exposure to global system for mobile communication electromagnetic fields (GSM-EMFs), 900 MHZ-induced electromagnetic radiation (EMR), on oxidative stress (OS) status, apoptotic, and ...
Mariam Salameh, Sukaina Zeitoun-Ghandour, Lina Sabra, Ahmad Daher, Mahmoud Khalil, Wissam H. Joumaa   +5 more
doaj   +1 more source

Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania. [PDF]

PLoS Pathogens, 2007
Trypanosomatids are unicellular protists that include the human pathogens Leishmania spp. (leishmaniasis), Trypanosoma brucei (sleeping sickness), and Trypanosoma cruzi (Chagas disease). Analysis of their recently completed genomes confirmed the presence
Frédéric Bringaud, Michaela Müller, Gustavo Coutinho Cerqueira, Martin Smith, Annie Rochette, Najib M A El-Sayed, Barbara Papadopoulou, Elodie Ghedin   +7 more
doaj   +1 more source