Results 61 to 70 of about 2,003,212 (358)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Predicting driving comfort in autonomous vehicles using road information and multi-head attention models

Nature Communications
Driving comfort is a crucial consideration in the automotive industry. In the realm of autonomous driving, comfort has always been a factor that requires continuous improvement.
Zhengxian Chen, Yuqi Liu, Wenjie Ni, Han Hai, Chaosheng Huang, Boyang Xu, Zihan Ling, Yang Shen, Wenhao Yu, Huanan Wang, Jun Li   +10 more
doaj   +1 more source

IFogSim2: An Extended iFogSim Simulator for Mobility, Clustering, and Microservice Management in Edge and Fog Computing Environments [PDF]

, 2021
Redowan Mahmud, Samodha Pallewatta, Mohammad Ali Goudarzi, Rajkumar Buyya   +3 more
openalex   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

More than a meeting: identifying the needs of the community-based seniors’ services sector as providers of health promotion services

BMC Research Notes, 2021
Objective Many economically developed countries have seen a decline in publicly funded community programming. Within this context, community-based seniors’ service (CBSS) organizations have been increasingly tasked to deliver programs to support the ...
Catherine E. Tong, Joanie Sims-Gould, Sarah Lusina-Furst, Heather McKay   +3 more
doaj   +1 more source

MEET: Mobility-Enhanced Edge inTelligence for Smart and Green 6G Networks [PDF]

, 2022
Yuxuan Sun, Bowen Xie, Sheng Zhou, Zhisheng Niu   +3 more
openalex   +1 more source

Aktiv mobil und vernetzt mobil - statt Auto-mobil

Internationales Verkehrswesen, 2022
In der autogerechten Stadt bekamen Zufußgehende das, was der Autoverkehr übrigließ, und Radfahrende gingen ganz leer aus. Nun sollen Straßen und Plätze (wieder) zu multifunktionalen Stadträumen werden – mit breiten Wegen für Fußverkehr, Aufenthalt, Erschließung und Bepflanzung sowie als Pufferzonen zur Fahrbahn.
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

COVID-19 lockdown induces disease-mitigating structural changes in mobility networks

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance During the COVID-19 pandemic, mobility restrictions have proved to be an effective mitigation strategy in many countries. To apply these measures more efficiently in the future, it is important to understand their effects in detail.
F. Schlosser, B. Maier, Olivia Jack, Dave Hinrichs, A. Zachariae, D. Brockmann   +5 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source