Results 71 to 80 of about 2,003,212 (358)

Hierarchical reinforcement learning for self‐driving decision‐making without reliance on labelled driving data

IET Intelligent Transport Systems, 2020
Decision making for self‐driving cars is usually tackled by manually encoding rules from drivers’ behaviours or imitating drivers’ manipulation using supervised learning techniques.
Jingliang Duan, Shengbo Eben Li, Yang Guan, Qi Sun, Bo Cheng   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Mobile Microfluidics [PDF]

Bioengineering, 2019
Microfluidics platforms can program small amounts of fluids to execute a bio-protocol, and thus, can automate the work of a technician and also integrate a large part of laboratory equipment. Although most microfluidic systems have considerably reduced the size of a laboratory, they are still benchtop units, of a size comparable to a desktop computer ...
openaire   +4 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Modeling freight truck-related traffic crash hazards with uncertainties: A framework of interpretable Bayesian neural network with stochastic variational inference

International Journal of Transportation Science and Technology
Due to the increasing demand for goods movement, externalities from freight mobility have attracted much concern among local citizens and policymakers.
Quan Yuan, Haocheng Lin, Chengcheng Yu, Chao Yang   +3 more
doaj   +1 more source

Rapidly adapting an effective health promoting intervention for older adults—choose to move—for virtual delivery during the COVID-19 pandemic

BMC Public Health, 2022
Background The COVID-19 (COVID) pandemic shifted way of life for all Canadians. ‘Stay-at-home’ public health directives counter transmission of COVID but may cause, or exacerbate, older adults’ physical and social health challenges.
Samantha M. Gray, Thea Franke, Joanie Sims-Gould, Heather A. McKay   +3 more
doaj   +1 more source

Hysteresis-Free High Mobility Graphene Encapsulated in Tungsten Disulfide [PDF]

, 2022
Karuppasamy Soundarapandian, Domenico De Fazio, Sefaattin Tongay, Frank H. L. Koppens   +3 more
openalex   +1 more source

Hydrogen Storage for Mobility: A Review

Materials, 2019
Numerous reviews on hydrogen storage have previously been published. However, most of these reviews deal either exclusively with storage materials or the global hydrogen economy.
É. Rivard, M. Trudeau, K. Zaghib
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Tariffs on electric vehicles deepen woes of U.S. electrification stagnation

npj Climate Action
Despite the U.S. climate ambitions requiring a 24% annual growth in EV sales, its EV market has experienced slow growth. Affordable EV imports could help break this stagnation, but the U.S. imposed high tariffs, to protect domestic auto industry.
Ming Liu, Xin Sun, Han Hao, Boyu Liu, Hao Dou, Haoyang Li, Zhenyu Dong, Yunfeng Deng, Lang Mai   +8 more
doaj   +1 more source