Results 71 to 80 of about 4,118,168 (395)

Climate mobilities: migration, im/mobilities and mobility regimes in a changing climate

Journal of Ethnic and Migration Studies, 2022
The discussion on the relation between human mobility and climate change has moved beyond linear and exceptional terms. Building on these debates, this article, and the Special Issue on Climate Mobilities: Migration, im/mobilities and mobilities regimes ...
Ingrid Boas, Hanne Wiegel, Carol Farbotko, J. Warner, M. Sheller   +4 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Evolution of mobility governance in Flanders: opening up for bottom-up initiatives or suffering from lock-in? [PDF]

, 2015
Mobility policy in Flanders lacks a clear discourse on implementing the policy objectives for 2020 and beyond. Though mobility planning can show success stories, mobility problems seem to aggravate.
Boelens, Luuk, Lauwers, Dirk, Van Brussel, Suzanne   +2 more
core   +1 more source

Aktiv mobil und vernetzt mobil - statt Auto-mobil

Internationales Verkehrswesen, 2022
In der autogerechten Stadt bekamen Zufußgehende das, was der Autoverkehr übrigließ, und Radfahrende gingen ganz leer aus. Nun sollen Straßen und Plätze (wieder) zu multifunktionalen Stadträumen werden – mit breiten Wegen für Fußverkehr, Aufenthalt, Erschließung und Bepflanzung sowie als Pufferzonen zur Fahrbahn.
openaire   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Predicting driving comfort in autonomous vehicles using road information and multi-head attention models

Nature Communications
Driving comfort is a crucial consideration in the automotive industry. In the realm of autonomous driving, comfort has always been a factor that requires continuous improvement.
Zhengxian Chen, Yuqi Liu, Wenjie Ni, Han Hai, Chaosheng Huang, Boyang Xu, Zihan Ling, Yang Shen, Wenhao Yu, Huanan Wang, Jun Li   +10 more
doaj   +1 more source

More than a meeting: identifying the needs of the community-based seniors’ services sector as providers of health promotion services

BMC Research Notes, 2021
Objective Many economically developed countries have seen a decline in publicly funded community programming. Within this context, community-based seniors’ service (CBSS) organizations have been increasingly tasked to deliver programs to support the ...
Catherine E. Tong, Joanie Sims-Gould, Sarah Lusina-Furst, Heather McKay   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Hierarchical reinforcement learning for self‐driving decision‐making without reliance on labelled driving data

IET Intelligent Transport Systems, 2020
Decision making for self‐driving cars is usually tackled by manually encoding rules from drivers’ behaviours or imitating drivers’ manipulation using supervised learning techniques.
Jingliang Duan, Shengbo Eben Li, Yang Guan, Qi Sun, Bo Cheng   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source