Results 61 to 70 of about 10,661,294 (296)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bio-Chemical Desensitization and Viscosity Reduction System for Ultra-Sensitive Heavy Oil Reservoirs in Jinjia Oilfield

Molecules
The Jinjia oilfield in Shengli oilfield is a typical ultra-sensitive reservoir characterized by high crude oil viscosity, poor fluidity, high clay content, and weak cementation. During development, oil-sand mixtures readily plug pore throats.
Xiangyu Zhang, Ningkai Shu, Wangang Zheng, Hongguang Xu, Jing Hu, Zhongping Zhang, Shuaidong Wang   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Time Difference Penalized Traffic Signal Timing by LSTM Q-Network to Balance Safety and Capacity at Intersections

IEEE Access, 2020
The conflict between limited road resources and rapid car ownership makes the traffic signal timing become a pivotal challenge. Emerging studies have been carried out on adaptive signal timing, but most of them still focus on the throughput of ...
Lyuchao Liao, Jierui Liu, Xinke Wu, Fumin Zou, Jengshyang Pan, Qi Sun, Shengbo Eben Li, Maolin Zhang   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

An Experimental Investigation of Surfactant-Stabilized CO₂ Foam Flooding in Carbonate Cores in Reservoir Conditions

Energies
Carbon dioxide (CO2) injection for enhanced oil recovery (EOR) has attracted great attention due to its potential to increase ultimate recovery from mature oil reservoirs.
Madiyar Koyanbayev, Randy Doyle Hazlett, Lei Wang, Muhammad Rehan Hashmet   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Effect of temperature and surfactant concentration on CO2 foam strength in Bentheimer sandstone at reservoir conditions

Journal of Petroleum Exploration and Production Technology
Surfactant-stabilized CO2 foams reduce CO2 mobility and improve CO2 sweep efficiency during CO2 enhanced oil recovery (EOR) and storage processes. However, the behavior of nonionic surfactant-stabilized CO2 foams near their cloud-point regions remain ...
Hilde Halsøy, Arne Graue, Zachary Paul Alcorn   +2 more
doaj   +1 more source