Results 91 to 100 of about 297,336 (298)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Experimental and numerical study on vibration-based damage detection and localisation in laminated composite plates

open access: yesFracture and Structural Integrity
Damage detection in composite materials is crucial for ensuring the safety and reliability of engineering structures. Conventional methods often face challenges in accurately identifying damage in plate-like structures, particularly in scenarios ...
Saeesh Verenkar   +3 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Mekanisme kekerasan simbolik dalam proses pendidikan formal di kota Palu

open access: yesJPPI (Jurnal Penelitian Pendidikan Indonesia)
Penelitian ini bertujuan untuk mengungkap mekanisme terjadinya kekerasan simbolik pada siswa SD di Kota Palu. Metode penelitian yang digunakan adalah penelitian kualitatif, teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi.
Arif Firmanyah   +5 more
doaj   +1 more source

Modal Realism with Modal Tense

open access: yesAustralasian Journal of Philosophy, 2008
Modal realists should fashion their theory by postulating and taking seriously the modal equivalent of tense, or modal tense. This will give them a uniform way to respond to five different objections, one each by Skyrms, Quine, and Peacocke, and two by van Inwagen, and suggest a non-Lewisian path to modal realism.
openaire   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

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