Results 101 to 110 of about 1,234,147 (346)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Analysis of Vibration Characteristics and Influencing Factors of Complex Tread Pattern Tires Based on Finite Element Method

Machines
The vibration of the tires significantly impacts a vehicle’s ride comfort and noise level; however, the current analysis of tire vibration characteristics often involves excessive simplification in their models, leading to a reduction in model accuracy ...
Mengdi Xu, Yunfei Ge, Xianbin Du, Zhaohong Meng   +3 more
doaj   +1 more source

Wilt Thou Be Lord of all the World? Modals and Persuasion in Shakespeare

Studia Anglica Posnaniensia, 2014
Persuasion is defined as human communication designed to influence the judgements and actions of others (Simons & Jones 2011). The purpose of this research is to analyse the discourse of persuasion in Shakespeare from the perspective of historical ...
Nakayasu Minako
doaj   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Relational Modality

Journal of Logic, Language and Information, 2008
Saul Kripke's thesis that ordinary proper names are rigid designators is supported by widely shared intuitions about the occurrence of names in ordinary modal contexts. By those intuitions names are scopeless with respect to the modal expressions. That is, sentences in a pair like Aristotle might have been fond of dogs Concerning Aristotle, it is ...
Pagin, Peter, Glüer, Kathrin
openaire   +4 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Is There a Modal Syllogistic?

Notre Dame Journal of Formal Logic, 1998
The paper deals with apodectic syllogistic. Supported by a close analysis of Aristotle's text, the author shows the right semantic restrictions on the principles of modal conversion as powerful enough to do all the work. The final conclusion is that any modal rules should be only modal versions (substitution instances) of ordinary nonmodal rules and ...
openaire   +4 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Operational Dynamic Load Testing for Repair Recommendations, Case Study of Access Road to Vehicle Weight in Motion

Dinamika Rekayasa
The indication of inaccuracies in vehicle weight measurement using Weight in Motion (WIM) technology on mining roads has been identified due to the non-fulfillment of the design criteria required by the WIM manufacturer.
Heri Khoeri, Dini Sofiana, Panji Nugroho, Rauzan Fikri Muthohari   +3 more
doaj   +1 more source

Modal Predicates

The Australasian Journal of Logic, 2004
Despite the wide acceptance of standard modal logic, there has always been a temptation to think that ordinary modal discourse may be correctly analyzed and adequately represented in terms of predicates rather than in terms of operators. The aim of the formal model outlined in this paper is to capture what I take to be the only plausible sense in which
openaire   +5 more sources