Results 71 to 80 of about 1,916,405 (251)

Impact Analysis of Modal Parameters of Marine Riser Based on Differential Transformation Method

Shiyou jixie, 2018
To study the change rule of modal parameters (natural frequency and vibration mode) of marine risers influenced by structural parameters (riser length and bending stiffness), axial tension (constant tension and variable tension), elastic restraint ...
Chen Wenli, Zhou Xingkun, Zheng Miaozi, Duan Menglan   +3 more
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Significance of low energy impact damage on modal parameters of composite beams by design of experiments [PDF]

, 2009
This paper presents an experimental study on the effects of multi-site damage on the vibration response of composite beams damaged by low energy impacts around the barely visible impact damage limit (BVID).
A Shahdin, J Morlier, Morlier, Joseph, Gourinat, Yves, Y Gourinat, Shahdin, Amir, Shahdin, A.   +6 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

PENGARUH PERPUTARAN MODAL KERJA, STRUKTUR MODAL DAN UKURAN PERUSAHAAN TERHADAP PROFITABILITAS PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI)

, 2014
Tujuan dari penelitian ini adalah untuk mengetahui pengaruh perputaran modal kerja, struktur modal dan ukuran perusahaan terhadap profitabilitas pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia pada tahun 2008-2011.
PENGARUH PERPUTARAN MODAL KERJA
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Modal parameter identification based on NEXT/ERA time-domain joint algorithm

上海师范大学学报. 自然科学版, 2015
This paper summarizes the basic idea of NEXT algorithm and features of the system, and the basic steps of implementation.On this basis,a modal identification program is written using Matlab.The monitoring data of East China Sea bridge are selected as an ...
WANG Hongwei
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparação de métodos de determinação do amortecimento estrutural através de técnicas de ajuste de curvas de funções resposta em frequência [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológio. Programa de Pós-Graduação em Engenharia Mecânica, Florianópolis, 2013A fenomenologia complexa dos mecanismos de amortecimento dos materiais e das estruturas impede a ...
Masotti, Diego
core