Results 61 to 70 of about 39,844 (267)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Shock and Vibration, 2020 The measured frequency response functions (FRFs) in the modal test are usually contaminated with noise that significantly affects the modal parameter identification.
Tianxu Zhu, Chaoping Zang, Gengbei Zhang
doaj +1 more source
Parameter Structures for Parametrized Modal Operators. [PDF]
, 1991 The parameters of the parametrized modal operators [p] and \Diamondp usually represent agents (in the epistemic interpretation) or actions (in the dynamic logic interpretation) or the like. In this paper the application of the idea of parametrized modal operators is extended in two ways: First of all a modified neighbourhood semantics is defined which ...
Ohlbach, H., Herzig, A.
openaire +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Parameter Equivalent Method of Stator Anisotropic Material Based on Modal Analysis
Energies, 2019 Accurate calculation of the vibration mode and natural frequency of a motor stator is the basis for reducing motor noise and vibration. However, the stator core and winding material parameters are difficult to determine, posing issues which result in ...
Zeyu Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Update of parameter matrices of the dynamic system using the least-squares approach
Advances in Mechanical Engineering, 2019 Model-based responses rarely coincide with the actual responses owing to modeling and measurement errors, deterioration of structural performance, and presence of damages in the structure.
Eun-Taik Lee, Hee-Chang Eun
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source