Results 41 to 50 of about 15,502 (266)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A New Maximum Likelihood Estimator Formulated in Pole-Residue Modal Model
Applied Sciences, 2019 Recently, a lot of efforts have been devoted to developing more precise Modal Parameter Estimation (MPE) techniques. This is explained by the necessity in civil, mechanical and aerospace engineering of obtaining accurate estimates for the modal ...
Sandro Amador +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Shock and Vibration, 2017 Modal parameter estimation plays an important role in vibration-based damage detection and is worth more attention and investigation, as changes in modal parameters are usually being used as damage indicators.
Zhi-Sai Ma, Li Liu, Si-Da Zhou, Lei Yu
doaj +1 more source
On-Line Modal Parameter Identification Applied to Linear and Nonlinear Vibration Absorbers
Actuators, 2020 A solution of the vibration attention problem on a flexible structure from a dynamic vibration absorption perspective is experimentally and numerically studied in this article.
Luis Gerardo Trujillo-Franco +4 more
doaj +1 more source
Modal parameters identification using asynchronous data
, 2020 Operational Modal Analysis (OMA) allows one to identify the modal parameters (e.g., natural frequencies, damping ratios and mode shapes) of structure from its output-only response to ambient excitations. Modal parameters are often studied to provide information for Structural Health Monitoring (SHM): model updating, damage detection, damage ...
Frigui, Farouk +3 more
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Advances in Mechanical Engineering, 2019 To accurately determine the temperature-dependent parameters of composites, a thermo-elastic parameter identification approach using thermal modal data is proposed in this article.
Dong Jiang +3 more
doaj +1 more source
Stochastic subspace identification of modal parameters during ice–structure interaction
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2019 Identifying the modal parameters of structures located in ice-infested waters may be challenging due to the interaction between the ice and structure. In this study, both simulated data from a state-of-the-art ice–structure interaction model and measured data of ice–structure interaction were both used in conjunction with a covariance-driven stochastic
Torodd S. Nord +2 more
openaire +7 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source