Results 51 to 60 of about 15,502 (266)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Modal parameter identification of all-GFRP composite cable-stayed footbridge in Denmark
MATEC Web of Conferences, 2017 The aim of this paper is to investigate of dynamic characteristics of cable-stayed Fiberline Bridge in Kolding, Denmark, made entirely of Glass Fiber Reinforced Polymer (GFRP) composite.
Górski Piotr +2 more
doaj +1 more source
Automated Modal Parameters Identification During Ice-Structure Interactions
Volume 2: Structures, Safety, and Reliability, 2022 Abstract Offshore structures are prone to damage caused by ice-induced vibrations. It is presently unknown to what extent different ice conditions change the properties of the structure, such as natural frequency, damping ratio, and mode shape.
Wang, Chunlin +2 more
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Applied Sciences, 2018 This paper proposes a fault identification method based on an improved stochastic subspace modal identification algorithm to achieve high-performance fault identification of dump truck suspension.
Bingwen Liu +4 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Modal parameter identification for a roof overflow powerhouse under ambient excitation
Water Science and Engineering, 2016 Modal parameter identification is a core issue in health monitoring and damage detection for hydraulic structures. For a roof overflow hydropower station with a bulb tubular unit under ambient excitation, a complex unit-powerhouse-dam coupling vibration ...
Yan Zhang, Ji-jian Lian, Fang Liu
doaj
Strain Modal Analysis of Small and Light Pipes Using Distributed Fibre Bragg Grating Sensors
Sensors, 2016 Vibration fatigue failure is a critical problem of hydraulic pipes under severe working conditions. Strain modal testing of small and light pipes is a good option for dynamic characteristic evaluation, structural health monitoring and damage ...
Jun Huang +5 more
doaj +1 more source
Identification of modal parameters using the wavelet transform
International Journal of Mechanical Sciences, 2002 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Lardies, Joseph, Gouttebroze, Stéphane
openaire +2 more sources