Results 81 to 90 of about 4,345,353 (297)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Computation of Real Normal Modes from Complex Eigenvectors [PDF]

open access: yes, 2006
A method for the computation of real normal modes from complex eigenvectors is described in this paper. The method is based on the exact eigensystem equations, which commonly cannot be used due the problem of modal truncation.
Füllekrug, Ulrich
core  

Intelligent Modal Analysis System: Autonomous Identification and Tracking of Aircraft Modal Parameters [PDF]

open access: yes
Efficient aircraft design necessitates lightweight constructions. However, this leads to aeroelastic challenges concerning loads and vibrations. One example is an unstable, self-excited vibration called flutter, which can result in structural failure. Flutter results from a coupling of one or more structural dynamic modes of the aircraft structure and ...
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Research of the Operational Modal Parameter Identification Technology and Application based on QICA

open access: yesJixie chuandong, 2015
Aiming at the major difficulties of OMA method based on vibration signals such as low noise-robust ability,high subjective experience and poor accuracy in identifying parameters and more complex recognition method,a new method of OMA on the basis of QICA
Zhang Rui   +5 more
doaj  

MEMS-Based Vibration Acquisition for Modal Parameter Identification of Substation Frame

open access: yesApplied Sciences
As a critical component of substations, the substation frames are characterized by significant height and span, which presents substantial challenges and risks in conducting dynamic response tests using traditional sensors. To simplify these difficulties,
Ruochen Qiang   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Estudo de comportamento dinamico de semi-eixo homocinetico com o uso de analise modal [PDF]

open access: yes, 1994
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro TecnologicoDevido ao constante avanço tecnológico da indústria automobilística, o desempenho vibratório de componentes veiculares atualmente ocupa destacada posição no aspecto de ...
Kniest, Rodrigo Rihl
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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