Results 61 to 70 of about 388,849 (304)
Identification and comparative analysis of vibration modal parameters of rice planter frame
AIP Advances, 2023 Modal parameter analysis is a common method for structural characteristic analysis. To accurately identify the modal parameters that describe the vibration characteristics of the structure, the chassis frame of the rice transplanter is taken as the ...
Kaikang Chen +7 more
doaj +1 more source
Testing the Importance of Fixing Exogenously Some Parameters in Aggregate Modal Split Models, by means of Sensitivity Analysis. [PDF]
, 1979 Aggregate modal split (and distribution) models currently need exogenously determined values for such key parameters as the value of in-vehicle time, the value of waiting time and the car occupancy factor.
Ortuzar, J.D.
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Correlating low energy impact damage with changes in modal parameters: diagnosis tools and FE validation [PDF]
, 2011 This paper presents a basic experimental technique and simplified FE based models for the detection, localization and quantification of impact damage in composite beams around the BVID level.
Abrate S. +16 more
core +3 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Applied SciencesThis paper presents a comparative study focused on a modal parameters estimation of specimens manufactured by the FDM technique using a fixed embedded vibrometer based on the laser Doppler principle and roving hammer-impact method.
Martin Hagara +4 more
doaj +1 more source