Results 71 to 80 of about 21,974 (265)

Prediction of Modal Parameters of Linear Time-Varying Systems [PDF]

Shock and Vibration, 2010
Many engineering structures, such as cranes, traffic-excited bridges, flexible mechanisms and robotic devices exhibit characteristics that vary with time and are referred to as time-varying or nonstationary. In particular, linear time-varying (LTV) systems have been often dealt with on a case-by-case basis.
MARCHESIELLO, STEFANO, BELLINO, ANDREA, GARIBALDI, Luigi   +2 more
openaire   +3 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Parameter Structures for Parametrized Modal Operators. [PDF]

, 1991
The parameters of the parametrized modal operators [p] and \Diamondp usually represent agents (in the epistemic interpretation) or actions (in the dynamic logic interpretation) or the like. In this paper the application of the idea of parametrized modal operators is extended in two ways: First of all a modified neighbourhood semantics is defined which ...
Ohlbach, H., Herzig, A.
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Characterizing the Dynamic Response of a Chassis Frame in a Heavy-Duty Dump Vehicle based on an Improved Stochastic System Identification

, 2015
This paper presents an online method for the assessment of the dynamic performance of the chassis frame in a heavy-duty dump truck based on a novel stochastic subspace identification (SSI) method. It introduces the use of an average correlation signal as
Chen, Zhi, Gu, Fengshou, Zhi Chen, Fengshou Gu, Tie Wang, Zhang, Ruiliang, Ruiliang Zhang, Jing, Peng, Wang, Tie   +8 more
core   +1 more source

Modal Parameters Estimation of Circular Plates Manufactured by FDM Technique Using Vibrometry: A Comparative Study

Applied Sciences
This paper presents a comparative study focused on a modal parameters estimation of specimens manufactured by the FDM technique using a fixed embedded vibrometer based on the laser Doppler principle and roving hammer-impact method.
Martin Hagara, Miroslav Pástor, Pavol Lengvarský, Peter Palička, Róbert Huňady   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Quantitative Study on the Modal Parameters Estimated Using the PLSCF and the MITD Methods and an Automated Modal Analysis Algorithm

, 2020
There are many advanced algorithms used to estimate modal parameters. In this paper, the modal parameters extracted from the Poly-reference Least Squares Complex Frequency (PLSCF) algorithm and the Multi-reference Ibrahim Time Domain (MITD) algorithm ...
A. Brandt, S. S. Christensen, M. Vanali, A. Cigada, S. Manzoni   +4 more
core   +1 more source