Results 71 to 80 of about 388,849 (304)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
NDT - Journal of Non-Destructive TestingOne of the most sensitive parts of a wind turbine to environmental influences are the rotating blades. Today, there are many technologies available to assess blade condition, but they all need to be developed to become more cost-effective and more ...
Aleksey Mironov +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
MEMS-Based Vibration Acquisition for Modal Parameter Identification of Substation Frame
Applied SciencesAs a critical component of substations, the substation frames are characterized by significant height and span, which presents substantial challenges and risks in conducting dynamic response tests using traditional sensors. To simplify these difficulties,
Ruochen Qiang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
International Journal of Automotive Engineering, 2019 A flexible ring-based model is simple, comprehensive, and accurate, and has been most frequently adopted in tire models with a low degree-of-freedom.
Masami Matsubara, Shozo Kawamura
doaj +1 more source
An auralisation method for real time subjective testing of modal parameters. [PDF]
, 2009 Subjective testing is necessary when attempting to determine the human response to audio quality. Small rooms, such as recording studio control rooms themselves have an effect upon the quality of the perceived audio reproduction.
Fazenda, Bruno, Wankling, Matthew
core
Fully Adaptive Gaussian Mixture Metropolis-Hastings Algorithm [PDF]
, 2013 Markov Chain Monte Carlo methods are widely used in signal processing and communications for statistical inference and stochastic optimization. In this work, we introduce an efficient adaptive Metropolis-Hastings algorithm to draw samples from generic ...
Luengo, David, Martino, Luca
core +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source