Results 71 to 80 of about 4,754,074 (251)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Modal Logics are Coalgebraic [PDF]

, 2008
Applications of modal logics are abundant in computer science, and a large number of structurally different modal logics have been successfully employed in a diverse spectrum of application contexts.
Pattinson, Dirk, Schröder, Lutz, Cirstea, Corina, Kurz, Alexander, Venema, Yde   +4 more
core   +2 more sources

Influence of Metro Vehicle Air Compressor Suspension Methods on Modal Parameters and Optimization of Vibration Reduction Forms

Chengshi guidao jiaotong yanjiu
［Objective］ Air compressor is one of the main sources for metro vehicle vibration excitation. Reasonable modal matching design for air compressor is conducive to reducing the vehicle body vibration and noise, thereby improving the riding comfort of the ...
CHEN Lei, LIU Zhonghua, LIU Zheng
doaj   +1 more source

Operational Modal Identification of Time-Varying Structures via a Vector Multistage Recursive Approach in Hybrid Time and Frequency Domain

Shock and Vibration, 2015
Real-time estimation of modal parameters of time-varying structures can conduct an obvious contribution to some specific applications in structural dynamic area, such as health monitoring, damage detection, and vibration control; the recursive algorithm ...
Si-Da Zhou, Li Liu, Wu Yang, Zhi-Sai Ma
doaj   +1 more source

A new modal analysis method applied to changing machine tool using clustering

Advances in Mechanical Engineering, 2020
The states of the machine tool, such as the components’ position and the spindle speed, play leading roles in the change of dynamic parameters. However, the traditional modal analysis method that modal parameters manually identified from vibration signal
Xuchu Jiang, Xinyong Mao, Yingjie Chen, Caihua Hao   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Real Time Estimation of Modal Parameters and Their Quality Assessment

Shock and Vibration, 2008
In this paper the recursive method for modal parameters estimation is formulated and verified. Formulated algorithms are implemented in the FPGA electronic chip.
Tadeusz Uhl, Maciej Petko, Grzegorz Karpiel, Andrzej Klepka   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source