Results 51 to 60 of about 18,357 (296)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Multi-domain substructures synthesis with general joints for the dynamics of large structures
AIP Advances, 2017 In this paper, a method for the assembly of multi-domain substructures with general joints is proposed. Modal domain and physical domain substructures can be coupled in a unified framework.
Shulin Chen +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Dynamic analysis of structures on multicore computers:Achieving efficiency through object oriented design [PDF]
, 2013 The paper examines software design aspects of implementing parallel and distributed computing for transient structural problems. Overall design is achieved using object and component oriented methods.
Mackie, R.I.
core +1 more source
Seismic response of nuclear fuel assembly
Applied and Computational Mechanics, 2014 The paper deals with mathematical modelling and computer simulation of the seismic response of fuel assembly components. The seismic response is investigated by numerical integration method in time domain.
Hlaváč Z., Zeman V.
doaj
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Vibration Analysis of Aeroengine Blisk Structure Based on a Prestressed CMS Super-Element Method
Shock and Vibration, 2016 For vibration analysis of aeroengine blisk structure, a prestressed component modal synthesis (CMS) super-element method is put forward with the fixed interface prestressing and free interface super-element approach.
Zhijun Li, Wenjun Yang, Huiqun Yuan
doaj +1 more source
Complexity, 2021 Acquiring complementary information about tissue morphology from multimodal medical images is beneficial to clinical disease diagnosis, but it cannot be widely used due to the cost of scans.
Zebin Hu +3 more
doaj +1 more source