Results 71 to 80 of about 133,377 (299)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Component mode synthesis and large deflection vibrations of complex structures [PDF]

The accuracy of the NASTRAN modal synthesis analysis was assessed by comparing it with full structure NASTRAN and nine other modal synthesis results using a nine-bay truss.
Mei, C.
core   +1 more source

Analysis of nonlinear structures via mode synthesis [PDF]

, 1975
An effective procedure for NASTRAN was developed that permits any number of substructures of any size to be synthesized for the purpose of developing normal modes of vibration of the complete structural system.
Gieseke, R. K.
core   +1 more source

Cycle-Consistent Deep Generative Hashing for Cross-Modal Retrieval

, 2018
In this paper, we propose a novel deep generative approach to cross-modal retrieval to learn hash functions in the absence of paired training samples through the cycle consistency loss.
Shao, Ling, Wang, Yang, Wu, Lin
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Simulation of Nonstationary Fluctuating Wind Fields Using POD Decoupling and Spline Interpolation

Buildings
Improving the simulation efficiency of the spectral representation method (SRM) for nonstationary fluctuating wind fields has attracted considerable attention.
Junfeng Zhang, Yuhang Xia, Ningbo Liu, Zheng Liu, Jie Li   +4 more
doaj   +1 more source

Vibration signature analysis of multistage gear transmission [PDF]

An analysis is presented for multistage multimesh gear transmission systems. The analysis predicts the overall system dynamics and the transmissibility to the gear box or the enclosed structure.
Choy, F. K., Savage, M., Townsend, D. P., Tu, Y. K.   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

RESEARCH AND SYNTHESIS OF THE MODAL REGULATOR OF THE TWO-MASS ELECTROMECHANICAL SYSTEM OF THE CRANE LIFTING MECHANISM

Известия высших учебных заведений: Проблемы энергетики, 2018
Research of operation electromechanical system with considering resilient liaison is an actual task. Resilient interactions between the engine and the mechanism increase the load on the mechanical transmission and working equipment and accelerate their ...
N. A. Malev, O. V. Pogoditsky
doaj   +1 more source

Multishaker modal testing [PDF]

A component mode synthesis method for damped structures was developed and modal test methods were explored which could be employed to determine the relevant parameters required by the component mode synthesis method.
Craig, R. R., Jr.
core   +1 more source