Results 81 to 90 of about 18,357 (296)

Design oriented simulation of contact-friction instabilities in application to realistic brake assemblies [PDF]

, 2010
This paper presents advances in non-linear simulations for systems with contact-friction, with an application to brake squeal. A method is proposed to orient component structural modifications from brake assembly simulations in the frequency and time ...
Lemaire, R., VERMOT DES ROCHES, Guillaume, BALMES, Etienne, PASQUET, Thierry, Pasquet, T., LEMAIRE, Rémi   +5 more
core  

Modal properties of the flexural vibrating package of rods linked by spacer grids

Applied and Computational Mechanics, 2011
The paper deals with the modelling and modal analysis of the large package of identical parallel rods linked by transverse springs (spacer grids) placed on several level spacings.
Zeman V., Hlaváč Z.
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A contribution for the experimental modal synthesis method

, 2006
The determination of the dynamic parameters of great or complex structures can be made using modal synthesis methods subdividing the complete structure in substructures.
Junqueira, Manoel Moraes
core  

Parametric Synthesis Model Controller for Nonlinear System Modal Control Method

, 2020
Рассмотрена методика синтеза ПИД-регулятора нелинейной системы управления. В качестве теоретической основы методики синтеза использован модальный метод.
Емельянов, Р.Т., Прокопьев, А.П., Emelyanov, Rurik T., Иванчура, В.И., Prokopev, Andrey P., Ivanchura, Vladimir I.   +5 more
core  

Frequency-Zooming ARMA Modeling for Analysis of Noisy String Instrument Tones

EURASIP Journal on Advances in Signal Processing, 2003
This paper addresses model-based analysis of string instrument sounds. In particular, it reviews the application of autoregressive (AR) modeling to sound analysis/synthesis purposes.
Esquef Paulo AA, Karjalainen Matti, Välimäki Vesa   +2 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A Modified Nonlinear Modal Synthesis Scheme for Mistuned Blisks with Synchronized Switch Damping

International Journal of Aerospace Engineering, 2018
In the authors’ previous work (MSSP 2017), we show that the synchronized switch damping based on negative capacitor (SSDNC) is a good candidate for vibration suppression of tuned blisks.
Jiuzhou Liu, Lin Li, Yu Fan, Xingrong Huang   +3 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source