Results 61 to 70 of about 133,377 (299)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

An efficient Generalized Geometry Contact algorithm including modal reduction flexible bodies

open access: yesMechanical Engineering Journal, 2017
In the MFBD (Multi-Flexible-Body Dynamics) (RecurDyn, 2017), the contact analysis is very important. To develop the general purpose contact algorithm for rigid and flexible bodies, the Generalized Geometry Contact algorithm, which is called ‘Geo Contact ...
Ho-Young CHA   +3 more
doaj   +1 more source

Type Synthesis Based on Modular Combination with Virtual Rotation Center and Application

open access: yesInternational Journal of Rotating Machinery, 2022
Type synthesis of mechanical structure is of great significance to the realization of mechanism target function, systematization, and stability of mechanical device.
Xinning Li   +6 more
doaj   +1 more source

Robust control of longitudinal flight with handling qualities constraints [PDF]

open access: yes, 2007
Classical flight control systems are still widely used in industry because of acquired experience and good understanding of their structure. Nevertheless, with more stringent constraints, it becomes difficult to easily fulfill all the criteria with ...
Akhrif, Ouassima   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Substructure elimination and binding method for vibration systems governed by a one-dimensional wave equation

open access: yesMechanical Engineering Journal
This paper presents a vibration analysis using the substructure elimination and binding method for vibration systems governed by a one-dimensional wave equation.
Keisuke YAMADA, Jinchen JI
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

STUDY ON FREE VIBRATION ANALYSIS FOR HONEYCOMB SANDWICH STRUCTURE WITH DOUBLE CORES

open access: yesJixie qiangdu, 2018
The free vibration problem of the honeycomb sandwich structure with double cores was studied based on the Layerwise/Solid-Elements( LW/SE) and Fixed-interface Modal Synthesis Technique( FMST) of the dynamic substructure method. The governing equation and
LU Xiang   +3 more
doaj  

Accuracy of results with NASTRAN modal synthesis [PDF]

open access: yes
A new method for component mode synthesis was developed for installation in NASTRAN level 17.5. Results obtained from the new method are presented, and these results are compared with existing modal synthesis ...
Herting, D. N.
core   +1 more source

Speech Processing in Computer Vision Applications [PDF]

open access: yes, 2020
Deep learning has been recently proven to be a viable asset in determining features in the field of Speech Analysis. Deep learning methods like Convolutional Neural Networks facilitate the expansion of specific feature information in waveforms, allowing ...
Waterworth, Nicholas
core   +2 more sources

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