Results 61 to 70 of about 18,357 (296)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Joint Camera-LiDAR Scene Synthesis and Perception for Autonomous Driving

IEEE Access
The advancement of autonomous driving and embedded AI systems has intensified the need for large-scale, richly annotated multimodal datasets encompassing RGB images, semantic labels, and 3D LiDAR data.
S. Raghavendra, S. K. Abhilash, Venu Madhav Nookala, P. V. Arun Kumar, B. N. Anoop, Ramyashree   +5 more
doaj   +1 more source

Type Synthesis Based on Modular Combination with Virtual Rotation Center and Application

International Journal of Rotating Machinery, 2022
Type synthesis of mechanical structure is of great significance to the realization of mechanism target function, systematization, and stability of mechanical device.
Xinning Li, Qishuo Zhang, Zongsu Zhang, Xianhai Yang, Hu Wu, Yongbo Li, Hailong Qu   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Turbine blade linkages in reduced modal synthesis model

, 2022
The paper is the first stage of our modelling turbine blade linkages in reduced modal synthesis model. The modal synthesis method is used for the dynamic behaviour studies of turbine bladed wheels with frictional inter-blade linkages and in case of the ...
Pešek, Luděk
core  

An efficient Generalized Geometry Contact algorithm including modal reduction flexible bodies

Mechanical Engineering Journal, 2017
In the MFBD (Multi-Flexible-Body Dynamics) (RecurDyn, 2017), the contact analysis is very important. To develop the general purpose contact algorithm for rigid and flexible bodies, the Generalized Geometry Contact algorithm, which is called ‘Geo Contact ...
Ho-Young CHA, Juhwan CHOI, Sungsoo RHIM, Jin Hwan CHOI   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An Abstract Tableau Calculus for the Description Logic SHOI Using UnrestrictedBlocking and Rewriting [PDF]

, 2012
This paper presents an abstract tableau calculus for the description logic SHOI. SHOI is the extension of ALC with singleton concepts, role inverse, transitive roles and role inclusion axioms.
Mohammad Khodadadi, Renate A Schmidt, Khodadadi, Mohammad, Schmidt, Renate A.; id_orcid, Tishkovsky, Dmitry   +3 more
core  

Substructure elimination and binding method for vibration systems governed by a one-dimensional wave equation

Mechanical Engineering Journal
This paper presents a vibration analysis using the substructure elimination and binding method for vibration systems governed by a one-dimensional wave equation.
Keisuke YAMADA, Jinchen JI
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source