Results 71 to 80 of about 1,760,547 (368)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Modes on the Move: Interval Cycles and the Emergence of Major-Minor Tonality
Empirical Musicology Review, 2011 The issue of the emergence of major-minor tonality is addressed by recourse to a novel pitch grouping process, referred to as interval cycle proximity (ICP).
Matthew Woolhouse
doaj +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Lietuvių Kalba, 2016 The present study examines the expression of modality in the 16th century texts of Old Lithuanian, namely in Jonas Bretkūnas’ Postilė (1591) and Mikalojus Daukša’s Postilė (1599).
Erika Jasionytė-Mikučionienė
doaj +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
, 2016 This special issue of the Canadian Journal of Philosophy is dedicated to Timothy Williamson's work on modality. It consists of a new paper by Williamson followed by papers on Williamson's work on modality, with each followed by a reply by Williamson.
McCullagh, Mark, Yli-Vakkuri, Juhani
core
Are emotions perceptual experiences of value? [PDF]
, 2012 A number of emotion theorists hold that emotions are perceptions of value. In this paper I say why they are wrong. I claim that in the case of emotion there is nothing that can provide the perceptual modality that is needed if the perceptual theory is to
Whiting, Demian
core +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Towards a Unified Knowledge-Based Approach to Modality Choice [PDF]
, 2007 This paper advances a unified knowledge-based approach to the process of choosing the most appropriate modality or combination of modalities in multimodal output generation.
Bachvarova, Yulia +2 more
core +1 more source
Robust Latent Representations via Cross-Modal Translation and Alignment [PDF]
ICASSP 2021, 2020 Multi-modal learning relates information across observation modalities of the same physical phenomenon to leverage complementary information. Most multi-modal machine learning methods require that all the modalities used for training are also available for testing.
arxiv