Results 141 to 150 of about 3,718,699 (318)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

La mode française sous l’occupation allemande dans le journal d’Andrzej Bobkowski 1940 –1944

open access: yesRevista Criação & Crítica, 2015
Bloqué à Paris en 1939 en route vers l’Amérique du Sud, Andrzej Bobkowski (1913–1961), écrivain et essayiste polonais, tient un journal intime durant la période de l’occupation allemande.
Krzysztof Trojanowski
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Non-linear discrete-time observer design by sliding mode

open access: yes, 2007
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University, 09/02/2007.Research into observer design for non-linear discrete-time systems has produced many design methods.
Algarawi, Mohammed
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

SemMode Mode et Littérature - 23 novembre, 14h30

open access: yes, 2018
Le prochain #SemMode a lieu le 23 novembre à 14h30 au 59/61 rue Pouchet, 75017 Paris. Il est consacré aux relations entre Mode et Littérature. Nous aurons le plaisir de recevoir: Alain Montandon, professeur émérite de Littérature Générale et Comparée,
Sophie Kurkdjian
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Semiconductor filled microstructured optical fibres with single mode guidance

open access: yes
Microstructured optical fibre (MOF) technology has generated new opportunities for the implementation of optical fibres with novel properties and functions [1].
Vukovic, N.   +3 more
core  

Car Ownership and Mode of Transport to Work in Ireland [PDF]

open access: yes
Rapid economic and demographic change in Ireland over the last decade, with associated increases in car dependence and congestion, has focused policy on encouraging more sustainable forms of travel.
Anne Nolan, Nicola Commins
core  

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