Results 71 to 80 of about 24,093 (263)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ANALYTICAL AND MODEL STUDY OF ACTIVE SEMICONDUCTOR CONVERTER IN ELECTRICAL DRIVE SYSTEMS [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2014 Mathematical description of the active semiconductor converter based on the main (smooth) component method and method of resulting vector is proposed.
S. G. German-Galkin +2 more
doaj
Control of a Boost Converter to Improve the Performance of a Photovoltaic System in a Microgrid
Proceedings, 2018 In this work, the analysis of a CD-CD converter type Boost is presented. This converter works in Discontinuous Conduction Mode; In addition, the design of its control loops is performed, using an Average Current Mode control.
Miguel Ángel Abundis Fong +4 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A novel TM01-TE01 high-power microwave mode converter
AIP Advances, 2019 This study presents the design and simulation of a novel type of TM01-TE01 mode converter for high-power microwave applications, which efficiently converts the TM01 circular waveguide mode into the TE01 circular waveguide mode.
Hongzhou Gong +3 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Jurnal Nasional Teknik Elektro, 2015 Bidirectional DC-DC converter is needed in the energy storage system. The converter topology used in this paper was a non-isolated bidirectional DC-DC buck-boost converter.
Eka Prasetyono +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source