Results 61 to 70 of about 24,093 (263)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Sliding mode control for DC/DC converters [PDF]

2012 IEEE 51st IEEE Conference on Decision and Control (CDC), 2012
In this paper, different sliding mode controls for DC/DC converters control are considered. Classical Buck, Boost and bidirectional Buck/Boost plants are presented for control application. A unified approach is adopted based on the mathematical tools of first- and second-order sliding mode output control.
CAVALLO, Alberto, Guida B.
openaire   +2 more sources

Simulations and Analysis and Operating Regime as Rectifier with Power Factor Correction of Two - Quadrant Converter with RNSIC

Advances in Electrical and Computer Engineering, 2009
In this paper, a new topology for a two-quadrant converter is presented. In the AC/DC transfer mode, the converter works as a rectifier with near sinusoidal input currents (RNSIC), while in the DC/AC transfer mode it works as a square-wave pulse ...
PLETEA, I.V., PLETEA, M., ALEXA, D., LUCANU, N.   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Silicon waveguide based TE mode converter

Optics Express, 2010
A silicon waveguide based TE mode converter was designed for the mode conversion between a horizontal waveguide and vertical waveguide in the two-layer structure waveguide based polarization diversity circuit. The TE mode converter's performance was studied.
Jing, Zhang, Tsung-Yang, Liow, Mingbin, Yu, Guo-Qiang, Lo, Dim-Lee, Kwong   +4 more
openaire   +2 more sources

Multiport bidirectional converters for off board charging stations of electric vehicles

Scientific Reports
In this paper, two multi-port bi-directional converters are proposed to be utilized as off-board Electric Vehicles (EVs) charging station. Both converters are designed to integrate renewable energy along with grid power.
Hazem H. Mostafa, Amr M. Ibrahim, Fathy Z. Amer, Eman F. Sawires   +3 more
doaj   +1 more source

Dual-edge modulated dual-switch Buck-Boost converter

Dianzi Jishu Yingyong, 2018
Dual-switch Buck-Boost has some advantages such as ground sharing between input and output, low switching device stress. Under the synchronous mode, the switch loss is serious.
Yuan Caiyuan, Su Shujing
doaj   +1 more source