Results 131 to 140 of about 431,603 (313)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Mean, Median or Mode? A Striking Conclusion From Lottery Experiments
This paper deals with estimating data from experiments determining lottery certainty equivalents. The paper presents the parametric and nonparametric results of the least squares (mean), quantile (including median) and mode estimations. The examined data
Kontek, Krzysztof
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Structural Dynamic Analysis of the Chenderoh Dam Sector Gate Section
MATEC Web of Conferences, 2018 The dynamic characteristics such as natural frequencies, mode shapes and frequency response function (FRF) are the important characteristics to be investigated to access the level of durability of any dam structures.
Ghazali Mohamad Hazwan Mohd +6 more
doaj +1 more source
Shaft mode shape demonstration
, 1985 The dynamic response of a rotating machine is directly influenced by its geometric configuration and all aspects of the rotor construction. These determine two significant parameters, mass distribution and stiffness, which yield a spectrum of natural ...
Grissom, R.
core
Experimental Investigation of Nonlinear Mode Shape in Microscale Beams [PDF]
, 2017 Undergraduate Research ScholarshipMicro-electro-mechanical-systems (MEMS) have drawn a great interest over last serval decades due to its wide applications including accelerometers and pressure sensors, micro-mirrors, radiofrequency (RF) switches ...
Ma, Min
core
On complex mode shapes and their identification
Journal of Physics: Conference SeriesAbstract In experimental modal analysis, proportional damping is a convenient simplification that allows practitioners to fit their data to a model. However, this simplification seriously reduces the number of free parameters for fitting, and some systems may be misrepresented by the assumption of proportional damping.
openaire +2 more sources
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source