Results 211 to 220 of about 1,998,737 (342)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Fs-Ablated Trenches on the Surface of Microsphere for Whispering Gallery Modes Cleaning. [PDF]

Micromachines (Basel)
Rizk HA, Simonov VA, Terentyev VS, Fedyaj VE, Simanchuk AE, Dostovalov AV, Babin SA.   +6 more
europepmc   +1 more source

Investigating the relation between complex mode shapes and local damage for structural assessment [PDF]

Maria Giovanna Masciotta, Daniele Pellegrini   +1 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Statistical Shape Modeling Approach for the Derivation of a Data-Driven Geometry-Aware Lumped Arterial Stenosis Model. [PDF]

Int J Numer Method Biomed Eng
Hilhorst PLJ, Verstraeten SCFPM, Zając K, Ganesan R, van 't Veer M, van de Vosse FN, Huberts W.   +6 more
europepmc   +1 more source

Demonstration of High-speed Indoor Optical Wireless Communications using Few-mode Based Uniform Beam Shaping

, 2020
Jianghao Li, Christina Lim, Ampalavanapillai Nirmalathas, Nicholas O’Keefe, Ka-Lun Lee   +4 more
openalex   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Morphological Similarities of Chronic Ankle Instability and Cavus Foot Type Using Statistical Shape Modeling. [PDF]

J Orthop Res
Lapins ER, Fendler A, LaTulip S, Nixon DC, Lenz AL.   +4 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Freeform Mode-Engineered Metasurfaces. [PDF]

Nano Lett
Jiang Z, Dai T, Guo S, Sohag SH, Shao Y, Mao C, Alù A, Fan JA, Zhou Y.   +8 more
europepmc   +1 more source