Results 131 to 140 of about 141,115 (295)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Harmonic scaling of mode shapes for operational modal analysis
, 2016 Mode shapes from operational modal analysis are normally unscaled, since the forces acting on the structure are not measured. Several methods for obtaining scaled mode shapes have been proposed in the past, some of them rather elaborate. In this paper we
Manzoni, S. +7 more
core +2 more sources
Fluid-structure interaction of submerged shells
, 1990 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A general three-dimensional hydroelasticity theory for the evaluation of responses has been adapted to formulate hydrodynamic coefficients for submerged ...
Randall, Richard John
core
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Dynamic monitoring of building structures on the example of the concert hall "Pushkinskiy" ramp in Moscow [PDF]
Инженерно-строительный журнал, 2012 In present time the free vibration method is not widely used in building survey practice. That is why the comparative database on initial dynamic object characteristics does not exist for the majority of buildings.
S.N. Savin
doaj
Damage localization by statistical evaluation of signal-processed mode shapes
, 2015 Due to their inherent ability to provide structural information on a local level, mode shapes and their derivatives are utilized extensively for structural damage identification.
Damkilde, Lars +1 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source