Results 161 to 170 of about 9,098,363 (304)

A model-based design strategy to engineer miRNA-regulated detection systems. [PDF]

Front Syst Biol
Verkuijlen RJ, Smith RW.
europepmc   +1 more source

Model-Based Design of Long-Distance Tracer Transport Experiments in Plants. [PDF]

Front Plant Sci, 2018
Bühler J, von Lieres E, Huber GJ.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Seamless monotherapy-combination phase I dose-escalation model-based design. [PDF]

Clin Trials
Daniells L, Jaki T, Dayimu A, Demiris N, Bristi B, Symeonides S, Mozgunov P.   +6 more
europepmc   +1 more source

Implementation of a Model-Based Design in a Phase Ib Study of Combined Targeted Agents. [PDF]

Clin Cancer Res, 2017
Wages NA, Portell CA, Williams ME, Conaway MR, Petroni GR.   +4 more
europepmc   +1 more source

Model-based User Interface Design

, 2002
This work is about supporting user interface design by means of explicit design representations, in particular models. We take as a starting point two different development traditions: the formal, analytic, topdown engineering approach and the informal, synthetic, bottom-up designer approach.
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Enabling Model-Based Design for Real-Time Spike Detection. [PDF]

IEEE Open J Eng Med Biol
Di Florio M, Bornat Y, Care M, Rosa Cota V, Buccelli S, Chiappalone M.   +5 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Model-based design of a mechanically intelligent shape-morphing structure. [PDF]

Sci Rep
Chen Q, Schott D, Jovanova J.
europepmc   +1 more source