Results 91 to 100 of about 3,497,010 (299)

Model-Based Systems Engineering Applied to Trade-Off Analysis of Wireless Power Transfer Technologies for Implanted Biomedical Microdevices. [PDF]

Sensors (Basel), 2021
Martínez Rojas JA, Fernández JL, Sánchez Montero R, López Espí PL, Diez-Jimenez E.   +4 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

A Model-Based Systems Engineering Approach for Effective Decision Support of Modern Energy Systems Depicted with Clean Hydrogen Production

Systems
A holistic approach to decision-making in modern energy systems is vital due to their increase in complexity and interconnectedness. However, decision makers often rely on narrowly-focused strategies, such as economic assessments, for energy system ...
Svetlana Lawrence, Daniel R. Herber
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Transdisciplinary model-based systems engineering in the development of the Ruminant Farm Systems model

Frontiers in Sustainability
This study adopts a transdisciplinary model-based systems engineering (MBSE) approach to support the development of the Ruminant Farm Systems (RuFaS) model, an advanced on-farm decision support tool.
Haowen Hu, Clifford A. Whitcomb, Thomas E. Ploetz, Kristan F. Reed, Kristan F. Reed   +4 more
doaj   +1 more source

Appropriate Models In Decision Support Systems For River Basin Management [PDF]

, 2004
In recent years, new ideas and techniques appear very quickly, like sustainability, adaptive management, Geographic Information System, Remote Sensing and participations of new stakeholders, which contribute a lot to the development of decision support ...
Booij, Martijn J., Xu, Yueping
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Model-Based Systems Engineering in Concurrent Engineering Centers [PDF]

Concurrent Engineering Centers (CECs) are specialized facilities with a goal of generating and maturing engineering designs by enabling rapid design iterations.
Bracken, Jennifer Medlin, Cole, Bjorn, Infeld, Samantha, Iwata, Curtis, Kisdi, Aron, McGuire, McQuirk, Christina, Murphy, Jonathan, Zarifian, Pezhman   +8 more
core   +4 more sources