Results 91 to 100 of about 11,397 (304)
Advanced Science, EarlyView.Facet‐engineered PVP‐capped CuFeSe2 nanocrystals exhibit potent, selective antifungal activity by strongly binding cell‐wall mannan, enabling vacuolar entry and organelle disruption. High‐index facets show superior mannan affinity, validated by theoretical calculations and experiments. CFS‐P induces vacuolar cavitation, mitochondrial abnormalities, and
Zhaohui Wang +10 more
wiley +1 more source
Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
Advanced Science, EarlyView.A physics‐informed property‐bridging framework links high‐throughput hardness screening to tensile performance in quenching and partitioning steels. By transferring metallurgically guided representations across properties, a single alloy composition is designed to achieve multiple strength grades through heat‐treatment tuning alone, offering a ...
Xiaolu Wei +7 more
wiley +1 more source
Model-Driven Architecture for Accelerating the Development of Tourism Applications
IEEE AccessThe tourism sector has witnessed a significant shift towards digital transformation, with mobile and web applications becoming essential tools for enhancing tourist experiences.
Lahbib Naimi +5 more
doaj +1 more source
User Oriented Approach in Information Communication Technology Research
Communications, 2017 User-oriented approach is changing the way of information systems development and affects the processes, methodologies and paradigms proposed by software architects and developers.
Zuzana Juchova Juroskova, Boris Bucko
doaj +1 more source
A model driven approach to building implementable model transformations [PDF]
The OMG's Model Driven Architecture (MDA) initiative has been the focus of much attention in both academia and industry, due to its promise of more rapid and consistent software development through the increased use of models.
Venkatesh, R. +4 more
core
CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
Digital Presentation and Preservation of Cultural and Scientific Heritage, 2018 Museum Space is an end-to-end Museum Management Software Suite developed to help Galleries, Libraries, Archives, and Museums (GLAM) make the World’s Cultural Treasure accessible to and meaningful for all.
Maria Todorova, Teodor Martev
doaj +1 more source
Semantic model-driven development of service-centric software architectures [PDF]
, 2007 Service-oriented architecture (SOA) is a recent architectural paradigm that has received much attention. The prevalent focus on platforms such as Web services, however, needs to be complemented by appropriate software engineering methods.
Pahl, Claus, Barrett, Ronan
core
Mapping EDOC to Web Services using YATL [PDF]
, 2004 Modeling is a technique used extensively in industry to define software systems, the UML being the most prominent example. With the increased use of modeling techniques has come the desire to use model transformations.
Patrascoiu, Octavian
core +1 more source