Results 141 to 150 of about 2,777,627 (313)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Model driven architecture and ontology development. [PDF]
, 2006 Defining a formal domain ontology is generally considered a useful, not to say necessary step in almost every software project. This is because software deals with ideas rather than with self-evident physical artefacts. However, this development step is hardly ever done, as ontologies rely on well-defined and semantically powerful AI concepts such as ...
Gašević, D. +2 more
openaire
Model-driven Development of Service-oriented Business Application Systems [PDF]
, 2009 The industrial development of real-world business applications that are based on service-oriented architecture (SOA) is subject to technological and organizational requirements.
Kätker, Stefan, Patig, Susanne
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
VIDEAS: Supporting Answer-Set Program Development using Model-Driven Engineering Techniques [PDF]
, 2011 Recently, the techniques of model-driven engineering (MDE) have been proven valuable to manage the complexity of modern software systems during the software development process.
Seidl, Martina +4 more
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Automatic PLC Control Logic Generation Method Based on SysML System Design Model
ActuatorsAutomatic generation of Programmable Logic Controller (PLC) programs from system design models can reduce system development costs and shorten system development cycles. However, effective methods for ensuring the quality and performance of control logic
Bo Ling, Changyong Chu, Chuan Xu
doaj +1 more source
Motorola WEAVR: Aspect Orientation [PDF]
, 2008 This paper presents an Aspect-Oriented Software Development (AOSD) language and methodology for Model-Driven Engineering (MDE) of large distributed applications, and a tool that implements these concepts, the Motorola WEAVR.
Model-driven Engineering
core
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source