Results 121 to 130 of about 2,777,627 (313)
04101 Discussion – A Taxonomy of Model Transformations [PDF]
, 2005 This report summarises the results of the discussions of a working group on model transformation of the Dagstuhl Seminar on Language Engineering for Model-Driven Software Development. The main contribution is a taxonomy of model transformation.
Mens, Tom +2 more
core +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Implementation-driven of Development Planning Model [PDF]
مدیریت دولتیObjectiveDespite Iran’s long history of national development planning and the considerable investment of human and financial resources, the country has not successfully realized the goals outlined in its plans.
Reza Vaezi +3 more
doaj +1 more source
Community driven development in fragile contexts [PDF]
, 2022 This review of community driven development discusses the incentive problems that arise when an external agency attempts to involve the local community in the planning and implementation of development projects.
Hatlebakk, Magnus
core
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Model Transformations Used in IT Project Initial Phases: Systematic Literature Review
ComputersThe paper emphasizes the critical importance of the initial phase in IT project development to avoid implementation errors. It argues that minimizing these errors can be achieved by developing project artifacts at the early stage using a model-driven ...
Oksana Nikiforova +7 more
doaj +1 more source