Results 101 to 110 of about 1,054,916 (264)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Automatic PLC Control Logic Generation Method Based on SysML System Design Model

open access: yesActuators
Automatic generation of Programmable Logic Controller (PLC) programs from system design models can reduce system development costs and shorten system development cycles. However, effective methods for ensuring the quality and performance of control logic
Bo Ling, Changyong Chu, Chuan Xu
doaj   +1 more source

Agile Model Driven Development of Electronic Health Record-Based Specialty Population Registries. [PDF]

open access: yesIEEE EMBS Int Conf Biomed Health Inform, 2016
Kannan V, Fish JC, Willett DL.
europepmc   +1 more source

Model driven architecture and ontology development. [PDF]

open access: yes, 2006
Defining a formal domain ontology is generally considered a useful, not to say necessary step in almost every software project. This is because software deals with ideas rather than with self-evident physical artefacts. However, this development step is hardly ever done, as ontologies rely on well-defined and semantically powerful AI concepts such as ...
Gašević, D.   +2 more
openaire  

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

LocSys: A Low-Code Paradigm for the Development of Cyber-Physical Applications

open access: yesSensors
Application development for the cyber-physical systems (CPS) domain is considered a quite complex procedure, since it not only requires a high level of expertise but also deep knowledge of heterogeneous domains.
Konstantinos Panayiotou   +2 more
doaj   +1 more source

Archetype Model-Driven Development Framework for EHR Web System. [PDF]

open access: yesHealthc Inform Res, 2013
Kobayashi S, Kimura E, Ishihara K.
europepmc   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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