Results 81 to 90 of about 2,777,627 (313)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Model-Driven Development of Web Augmenters for Facilitating Environmental Open Data Consumption

IEEE Access
Citizens must consume open data published by public institutions to be aware of environmental issues of SDGs (Sustainable Development Goals). However, the existence of many related heterogeneous open data sets hampers citizens to access and consume them ...
Paula Gonzalez-Martinez, Cesar Gonzalez-Mora, Irene Garrigos, Jose-Norberto Mazon, Jose M. Cecilia   +4 more
doaj   +1 more source

Testing of model-driven development applications

Software Quality Journal, 2016
Human resource management practices are key for the success of software development projects. Practices that promote knowledge sharing and organizational learning are positively related to development–effort curves, and thus software companies are looking for different alternatives oriented to promoting these practices. The modeldriven development (MDD)
Beatriz Marín, Carlos Gallardo, Diego Quiroga, Giovanni Giachetti, Estefanía Serral   +4 more
openaire   +2 more sources

Embedding Requirements within the Model Driven Architecture [PDF]

, 2011
The Model Driven Architecture (MDA) brings benefits to software development, among them the potential for connecting software models with the business domain. This paper focuses on the upstream or Computation Independent Model (CIM) phase of the MDA. Our
Phalp, Keith T., Kanyaru, J.M., Jeary, Sherry, Fouad, A.   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Inter-American Development Bank Annual Report 2004 [PDF]

, 2005
This Annual Report contains a brief summary of the economic situation of Latin America and the Caribbean and a review of the Bank\u27s operations in 2004.
Inter-American Development Bank
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Universal Framework for Skill-Based Cyber-Physical Production Systems

Journal of Manufacturing and Materials Processing
In the vision of smart manufacturing and Industry 4.0, it is vital to automate production processes. There is a significant gap in current practices, where the derivation of production processes from product data still heavily relies on human expertise ...
Max Hossfeld, Andreas Wortmann
doaj   +1 more source

Software Architecture and Framework to Develop NFC-Based Applications

Sensors, 2018
Applications are employing Near Field Communication (NFC) technology to interact with physical objects by using NFC tags. The architecture to implement these kinds of applications varies according to non-functional requirements such as the physical ...
Ricardo Tesoriero, Jose A. Gallud
doaj   +1 more source

Model-driven development of pervasive applications using context and ontologies: an m-commerce case study [PDF]

, 2009
The widespread use of handheld devices significantly motivates the growth of mobile commerce (m-commerce) that enables end-users to access, buy and sell goods and services whilst on the move.
Georgalas, N., Economou, D.
core