Results 91 to 100 of about 2,777,627 (313)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Model-based approach for specifying requirements of virtual reality software products

open access: yesFrontiers in Virtual Reality
IntroductionGathering requirements for developing virtual reality (VR) software products is a labor-intensive process. It requires detailed elicitation of scene flow, articles in the scene, action responses, custom behaviors, and timeline of events.
Sai Anirudh Karre, Y. Raghu Reddy
doaj   +1 more source

Intents and Upgrades in Component-Based High-Assurance Systems [PDF]

open access: yes, 2005
ion is the most basic principle of software engineering. Abstractions are provided by models. Modeling and model transformation constitute the core of model-driven development.
Elmquist, Jonas,, Nadjm-Tehrani, Simin,
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Novel Reference Method for the Characterization of PD Measuring Systems Using HFCT Sensors

open access: yesSensors
During their lifespan, high-voltage (HV) electrical systems are subjected to operating conditions in which electrical, mechanical, thermal and environmental-related stresses occur.
Eduardo Arcones   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Model-Driven Development

open access: yes, 2009
The purpose of this publication is to describe the state-of-the-art and results of two surveys about the model-driven development (MDD), particularly from the processes viewpoint. The study and surveys were carried out in the "Model-driven development of highly configurable embedded Software-intensive Systems (MoSiS)" ITEA project.
Takalo Juha   +3 more
openaire   +1 more source

Model Driven Architecture and Modeling Driven Software Development [PDF]

open access: yes
The monography is a proceeding of the papers presented at the 3rd 3rd International Workshop on Model Driven Architecture and Modeling Driven Software Development In conjinction with the 6th International Conference on Evaluation of Novel Approaches to ...
Ņikiforova, Oksana, Osis, Jānis
core  

Extending the Model Driven Architecture with a preCIM level [PDF]

open access: yes, 2008
Whilst the successful alignment of business strategy and IT development is an important topic, there are still few ways that this is possible. The Model Driven Architecture (MDA) shows promise as an approach but is focussed firmly in the IT domain at ...
Phalp, Keith T.   +2 more
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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