Results 71 to 80 of about 952,227 (243)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

CodingBlind: Automated Cloud Services Generation From Printed Forms and BPMN

IEEE Access, 2018
Cloud service is a new trend in constructing enterprise applications. However, implementing cloud services is time consuming, costly, and error prone. Moreover, there are concerns about the isolation and flexibility of multitenancy cloud services.
Han Yu, Congcong Ye, Hongming Cai, Lihong Jiang, Cheng Xie, Boyi Xu   +5 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Edge IoT Prototyping Using Model-Driven Representations: A Use Case for Smart Agriculture

Sensors
Industry 4.0 is positioned at the junction of different disciplines, aiming to re-engineer processes and improve effectiveness and efficiency. It is taking over many industries whose traditional practices are being disrupted by advances in technology and
Ivan Guevara, Stephen Ryan, Amandeep Singh, Colm Brandon, Tiziana Margaria   +4 more
doaj   +1 more source

INDIeAuthor: A Metamodel-Based Textual Language for Authoring Educational Courses

IEEE Access, 2019
This paper presents the INDIeAuthor authoring tool, which has been developed at the Digital Content Production Center, Polytechnic University of Cartagena (UPCT).
Daniel Perez-Berenguer, Jesus Garcia-Molina   +1 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Scale Modular Test Platform for the Characterization of PD Measuring Systems Using HFCT Sensors

Sensors
Today, online partial discharge (PD) measurements are common practice to assess the condition status of dielectrics in high-voltage (HV) electrical grids.
Eduardo Arcones, Fernando Álvarez, Abderrahim Khamlichi, Fernando Garnacho   +3 more
doaj   +1 more source

Simulation of Road Traffic Applying Model-Driven Engineering

Advances in Distributed Computing and Artificial Intelligence Journal, 2016
Road traffic is an important phenomenon in modern societies. The study of its different aspects in the multiple scenarios where it happens is relevant for a huge number of problems.
Alberto FERNÁNDEZ-ISABEL, Rubén FUENTES-FERNÁNDEZ   +1 more
doaj   +1 more source